Pharmacological characterization of potent and selective Na_V1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V

• Bryan D. Moyer ,

  Roles Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: bmoyer@amgen.com

  Affiliation Neuroscience, Amgen Discovery Research, Thousand Oaks, California, United States of America

  http://orcid.org/0000-0002-5548-3148

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• Justin K. Murray,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  Affiliation Therapeutic Discovery, Amgen Discovery Research, Thousand Oaks, California, United States of America

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• Joseph Ligutti,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Neuroscience, Amgen Discovery Research, Thousand Oaks, California, United States of America

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• Kristin Andrews,

  Roles Formal analysis, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Molecular Engineering, Amgen Discovery Research, Cambridge, Massachusetts, United States of America

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• Philippe Favreau,

  Roles Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Atheris Laboratories, CH Bernex, Geneva, Switzerland

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• John B. Jordan,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Discovery Attribute Sciences, Amgen Discovery Research, Thousand Oaks, California, United States of America

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• Josie H. Lee,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Neuroscience, Amgen Discovery Research, Cambridge, Massachusetts, United States of America

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• Dong Liu,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Neuroscience, Amgen Discovery Research, Thousand Oaks, California, United States of America

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• Jason Long,

  Roles Formal analysis, Investigation, Resources, Writing – review & editing

  Affiliation Therapeutic Discovery, Amgen Discovery Research, Thousand Oaks, California, United States of America

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• Kelvin Sham,

  Roles Formal analysis, Investigation, Resources, Writing – review & editing

  Affiliation Therapeutic Discovery, Amgen Discovery Research, Thousand Oaks, California, United States of America

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• Licheng Shi,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Neuroscience, Amgen Discovery Research, Thousand Oaks, California, United States of America

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• Reto Stöcklin,

  Roles Formal analysis, Investigation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Atheris Laboratories, CH Bernex, Geneva, Switzerland

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• Bin Wu,

  Roles Formal analysis, Investigation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Therapeutic Discovery, Amgen Discovery Research, Thousand Oaks, California, United States of America

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• Ruoyuan Yin,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Neuroscience, Amgen Discovery Research, Thousand Oaks, California, United States of America

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• Violeta Yu,

  Roles Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Neuroscience, Amgen Discovery Research, Cambridge, Massachusetts, United States of America

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• Anruo Zou,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Neuroscience, Amgen Discovery Research, Thousand Oaks, California, United States of America

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• Kaustav Biswas,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Therapeutic Discovery, Amgen Discovery Research, Thousand Oaks, California, United States of America

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•  [ ... ],
• Les P. Miranda

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Therapeutic Discovery, Amgen Discovery Research, Thousand Oaks, California, United States of America

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