CUL5 is required for thalidomide-dependent inhibition of cellular proliferation

Bryan Kunkler; Daniel Salamango; Zachary J. DeBruine; Caitlin Ploch; Shirley Dean; David Grossens; Michael P. Hledin; Gabriel A. Marquez; Julie Madden; Abigayle Schnell; Michael Short; Maria A. Burnatowska-Hledin

doi:10.1371/journal.pone.0196760

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Open Access

Peer-reviewed

Research Article

CUL5 is required for thalidomide-dependent inhibition of cellular proliferation

Bryan Kunkler,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

Affiliation Department of Chemistry, Paul A. Schaap Science Center, Hope College, Holland, MI, United States of America
⨯
Daniel Salamango,

Roles Investigation, Methodology, Writing – original draft

Affiliation Department of Chemistry, Paul A. Schaap Science Center, Hope College, Holland, MI, United States of America
⨯
Zachary J. DeBruine,

Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Department of Chemistry, Paul A. Schaap Science Center, Hope College, Holland, MI, United States of America
⨯
Caitlin Ploch,

Roles Formal analysis, Investigation

Affiliation Department of Chemistry, Paul A. Schaap Science Center, Hope College, Holland, MI, United States of America
⨯
Shirley Dean,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Chemistry, Paul A. Schaap Science Center, Hope College, Holland, MI, United States of America
⨯
David Grossens,

Roles Investigation, Methodology

Affiliation Department of Chemistry, Paul A. Schaap Science Center, Hope College, Holland, MI, United States of America
⨯
Michael P. Hledin,

Roles Investigation

Affiliation Department of Chemistry, Paul A. Schaap Science Center, Hope College, Holland, MI, United States of America
⨯
Gabriel A. Marquez,

Roles Investigation

Affiliation Department of Chemistry, Paul A. Schaap Science Center, Hope College, Holland, MI, United States of America
⨯
Julie Madden,

Roles Investigation, Methodology

Affiliation Department of Chemistry, Paul A. Schaap Science Center, Hope College, Holland, MI, United States of America
⨯
Abigayle Schnell,

Roles Investigation, Validation

Affiliation Department of Chemistry, Paul A. Schaap Science Center, Hope College, Holland, MI, United States of America
⨯
Michael Short,

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliation Department of Chemistry, Paul A. Schaap Science Center, Hope College, Holland, MI, United States of America
⨯
Maria A. Burnatowska-Hledin

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft

* E-mail: hledin@hope.edu

Affiliations Department of Chemistry, Paul A. Schaap Science Center, Hope College, Holland, MI, United States of America, Department of Biology, Paul A. Schaap Science Center, Hope College, Holland, MI, United States of America

http://orcid.org/0000-0003-2962-7424

⨯

CUL5 is required for thalidomide-dependent inhibition of cellular proliferation

Bryan Kunkler,
Daniel Salamango,
Zachary J. DeBruine,
Caitlin Ploch,
Shirley Dean,
David Grossens,
Michael P. Hledin,
Gabriel A. Marquez,
Julie Madden,
Abigayle Schnell

Published: May 10, 2018
https://doi.org/10.1371/journal.pone.0196760

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Transfection
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Small interfering RNA
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Endothelial cells
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Cancer treatment
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Cell growth
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Angiogenesis
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HIV infections
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Ligases
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