Directed fusion of cardiac spheroids into larger heterocellular microtissues enables investigation of cardiac action potential propagation via cardiac fibroblasts

• Tae Yun Kim ,

  Contributed equally to this work with: Tae Yun Kim, Celinda M. Kofron

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Cardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, United States of America

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• Celinda M. Kofron ,

  Contributed equally to this work with: Tae Yun Kim, Celinda M. Kofron

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Cardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, United States of America, Center for Biomedical Engineering, School of Engineering, Brown University, Providence, RI, United States of America

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• Michelle E. King,

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation Cardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, United States of America

  http://orcid.org/0000-0003-1457-4497

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• Alexander R. Markes,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliations Cardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, United States of America, Division of Biology and Medicine, Brown University, Providence, RI, United States of America

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• Amenawon O. Okundaye,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliations Cardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, United States of America, Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI, United States of America

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• Zhilin Qu,

  Roles Software, Writing – review & editing

  Affiliation Division of Cardiology, Department of Medicine, University of California, Los Angeles, CA, United States of America

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• Ulrike Mende ,

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: ulrike_mende@brown.edu (UM); bum-rak_choi@brown.edu (B-RC)

  ¶‡ These authors contributed equally as senior authors on this work.

  Affiliation Cardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, United States of America

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• Bum-Rak Choi

  Roles Conceptualization, Data curation, Formal analysis, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: ulrike_mende@brown.edu (UM); bum-rak_choi@brown.edu (B-RC)

  ¶‡ These authors contributed equally as senior authors on this work.

  Affiliation Cardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, United States of America

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