Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory

• Kosuke Okuda,

  Roles Formal analysis, Funding acquisition, Investigation, Visualization, Writing – original draft

  Affiliation Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

  ⨯
• Keizo Takao,

  Roles Formal analysis, Funding acquisition, Investigation, Supervision

  Current address: Division of Animal Resources and Development, Life Science Research Center, University of Toyama, Toyama, Toyama, Japan

  Affiliation Section of Behavior Patterns, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki, Aichi, Japan

  ⨯
• Aya Watanabe,

  Roles Resources

  Affiliation Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

  ⨯
• Tsuyoshi Miyakawa,

  Roles Funding acquisition, Methodology, Resources, Software, Supervision

  Affiliations Section of Behavior Patterns, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki, Aichi, Japan, Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan

  ⨯
• Masashi Mizuguchi,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

  ⨯
• Teruyuki Tanaka

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: tetanaka@m.u-tokyo.ac.jp

  Affiliation Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

  http://orcid.org/0000-0003-2000-5354

  ⨯