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Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice
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Leah M. Prentice ,
Roles Conceptualization, Data curation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: lprentice@contextualgenomics.com
Affiliation Contextual Genomics Incorporated, Vancouver, British Columbia, Canada
⨯ - Ruth R. Miller,
- Jeff Knaggs,
- Alborz Mazloomian,
- Rosalia Aguirre Hernandez,
- Patrick Franchini,
- Kourosh Parsa,
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Basile Tessier-Cloutier,
Roles Data curation
Affiliation Anatomical Pathology, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
⨯ - Anna Lapuk,
- David Huntsman,
- David F. Schaeffer,
- Brandon S. Sheffield
http://orcid.org/0000-0001-8011-2835
Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice
- Leah M. Prentice,
- Ruth R. Miller,
- Jeff Knaggs,
- Alborz Mazloomian,
- Rosalia Aguirre Hernandez,
- Patrick Franchini,
- Kourosh Parsa,
- Basile Tessier-Cloutier,
- Anna Lapuk,
- David Huntsman
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- Published: April 26, 2018
- https://doi.org/10.1371/journal.pone.0196434