Fc engineering of anti-Nectin-2 antibody improved thrombocytopenic adverse event in monkey

Tsutomu Oshima; Hideaki Miyashita; Yoshimasa Ishimura; Yuki Ito; Yoko Tanaka; Akira Hori; Toshio Kokubo; Tomofumi Kurokawa

doi:10.1371/journal.pone.0196422

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Open Access

Peer-reviewed

Research Article

Fc engineering of anti-Nectin-2 antibody improved thrombocytopenic adverse event in monkey

Tsutomu Oshima ,

Roles Data curation, Formal analysis, Investigation, Validation, Writing – original draft

* E-mail: tsutomu.oshima@takeda.com

Affiliation Immunobiologics, Takeda California Inc., San Diego, California, United States of America

http://orcid.org/0000-0002-3448-984X

⨯
Hideaki Miyashita,

Roles Data curation, Investigation, Writing – original draft

Affiliation Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, Hikari, Yamaguchi, Japan
⨯
Yoshimasa Ishimura,

Roles Data curation, Formal analysis, Validation, Writing – original draft

Current address: Biology Laboratory, SCOHIA PHARMA Inc., Fujisawa, Kanagawa, Japan

Affiliation Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Yuki Ito,

Roles Data curation, Formal analysis, Validation, Writing – original draft

Affiliation Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Yoko Tanaka,

Roles Data curation, Writing – original draft

Affiliation Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, Hikari, Yamaguchi, Japan
⨯
Akira Hori,

Roles Investigation, Writing – review & editing

Affiliation Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Toshio Kokubo,

Roles Supervision, Writing – review & editing

Current address: International Institute for Integrative Sleep Medicine, Tsukuba University, Tsukuba, Ibaragi, Japan

Affiliation Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Tomofumi Kurokawa

Roles Conceptualization, Investigation, Project administration, Supervision, Writing – review & editing

Current address: Pharmacology Laboratories, Taisho Pharmaceutical Company Limited, Saitama, Saitama, Japan

Affiliation Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯

Fc engineering of anti-Nectin-2 antibody improved thrombocytopenic adverse event in monkey

Tsutomu Oshima,
Hideaki Miyashita,
Yoshimasa Ishimura,
Yuki Ito,
Yoko Tanaka,
Akira Hori,
Toshio Kokubo,
Tomofumi Kurokawa

Published: May 3, 2018
https://doi.org/10.1371/journal.pone.0196422

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