Megakaryocyte lineage development is controlled by modulation of protein acetylation

Marije Bartels; Anita Govers; Roel Polak; Stephin Vervoort; Ruben van Boxtel; Cornelieke Pals; Marc Bierings; Wouter van Solinge; Toine Egberts; Edward Nieuwenhuis; Michal Mokry; Paul James Coffer

doi:10.1371/journal.pone.0196400

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Open Access

Peer-reviewed

Research Article

Megakaryocyte lineage development is controlled by modulation of protein acetylation

Marije Bartels ,

Contributed equally to this work with: Marije Bartels, Anita Govers

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

Affiliations Center for Molecular Medicine and Regenerative Medicine Center, University Medical Center Utrecht, Utrecht, The Netherlands, Division of Pediatrics, University Medical Center Utrecht, Utrecht, the Netherlands
⨯
Anita Govers ,

Contributed equally to this work with: Marije Bartels, Anita Govers

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

Affiliations Center for Molecular Medicine and Regenerative Medicine Center, University Medical Center Utrecht, Utrecht, The Netherlands, Division of Pediatrics, University Medical Center Utrecht, Utrecht, the Netherlands
⨯
Roel Polak,

Roles Investigation

Affiliation Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
⨯
Stephin Vervoort,

Roles Formal analysis

Affiliation Center for Molecular Medicine and Regenerative Medicine Center, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Ruben van Boxtel,

Roles Formal analysis

Affiliation Department of Developmental Biology and Stem Cell Research, Hubrecht Institute, Utrecht, the Netherlands
⨯
Cornelieke Pals,

Roles Investigation

Affiliation Center for Molecular Medicine and Regenerative Medicine Center, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Marc Bierings,

Roles Conceptualization

Affiliation Division of Pediatrics, University Medical Center Utrecht, Utrecht, the Netherlands
⨯
Wouter van Solinge,

Roles Data curation

Affiliation Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, the Netherlands
⨯
Toine Egberts,

Roles Data curation

Affiliations Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, the Netherlands, Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Edward Nieuwenhuis,

Roles Conceptualization

Affiliation Division of Pediatrics, University Medical Center Utrecht, Utrecht, the Netherlands
⨯
Michal Mokry,

Roles Conceptualization, Data curation, Formal analysis

Affiliation Division of Pediatrics, University Medical Center Utrecht, Utrecht, the Netherlands
⨯
Paul James Coffer

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: p.j.coffer@umcutrecht.nl

Affiliations Center for Molecular Medicine and Regenerative Medicine Center, University Medical Center Utrecht, Utrecht, The Netherlands, Division of Pediatrics, University Medical Center Utrecht, Utrecht, the Netherlands

http://orcid.org/0000-0002-8332-6828

⨯

Megakaryocyte lineage development is controlled by modulation of protein acetylation

Marije Bartels,
Anita Govers,
Roel Polak,
Stephin Vervoort,
Ruben van Boxtel,
Cornelieke Pals,
Marc Bierings,
Wouter van Solinge,
Toine Egberts,
Edward Nieuwenhuis

Published: April 26, 2018
https://doi.org/10.1371/journal.pone.0196400

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Megakaryocytes
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Cell differentiation
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Acetylation
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