Glycan modifications to the gp120 immunogens used in the RV144 vaccine trial improve binding to broadly neutralizing antibodies

Rachel C. Doran; Gwen P. Tatsuno; Sara M. O’Rourke; Bin Yu; David L. Alexander; Kathryn A. Mesa; Phillip W. Berman

doi:10.1371/journal.pone.0196370

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Open Access

Peer-reviewed

Research Article

Glycan modifications to the gp120 immunogens used in the RV144 vaccine trial improve binding to broadly neutralizing antibodies

Rachel C. Doran ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft

* E-mail: racdoran@soe.ucsc.edu

Affiliations Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, United States of America, Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, United States of America

http://orcid.org/0000-0002-2032-1528

⨯
Gwen P. Tatsuno,

Roles Conceptualization, Resources

Affiliation Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, United States of America
⨯
Sara M. O’Rourke,

Roles Methodology, Supervision, Writing – review & editing

Affiliation Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, United States of America
⨯
Bin Yu,

Roles Investigation

Affiliation Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, United States of America
⨯
David L. Alexander,

Roles Resources, Supervision

Affiliation Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, United States of America
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Kathryn A. Mesa,

Roles Investigation, Resources, Writing – review & editing

Affiliation Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, United States of America
⨯
Phillip W. Berman

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, United States of America, Gladstone Institute of Virology & Immunology, San Francisco, California, United States of America

http://orcid.org/0000-0003-2462-1592

⨯

Glycan modifications to the gp120 immunogens used in the RV144 vaccine trial improve binding to broadly neutralizing antibodies

Rachel C. Doran,
Gwen P. Tatsuno,
Sara M. O’Rourke,
Bin Yu,
David L. Alexander,
Kathryn A. Mesa,
Phillip W. Berman

Published: April 24, 2018
https://doi.org/10.1371/journal.pone.0196370

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