Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro

• Esther M. Speer ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – original draft

  * E-mail: esther.speer@stonybrookmedicine.edu

  Affiliation Department of Pediatrics, Division of Neonatology, Stony Brook University School of Medicine, Stony Brook, New York, United States of America

  http://orcid.org/0000-0001-8382-4897

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• David J. Dowling,

  Roles Conceptualization, Methodology, Visualization, Writing – review & editing

  Affiliations Department of Medicine, Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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• Jianjin Xu,

  Roles Formal analysis, Resources, Software, Writing – review & editing

  Affiliation Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York, United States of America

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• Lukasz S. Ozog,

  Roles Data curation, Investigation, Validation

  Affiliation Department of Pediatrics, Division of Neonatology, Stony Brook University School of Medicine, Stony Brook, New York, United States of America

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• Jaime A. Mathew,

  Roles Investigation, Validation

  Affiliation Department of Pediatrics, Division of Neonatology, Stony Brook University School of Medicine, Stony Brook, New York, United States of America

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• Avinash Chander,

  Roles Conceptualization, Methodology, Resources, Writing – review & editing

  Affiliation Department of Pediatrics, Division of Neonatology, Stony Brook University School of Medicine, Stony Brook, New York, United States of America

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• Donglei Yin,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York, United States of America

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• Ofer Levy

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Visualization, Writing – review & editing

  Affiliations Department of Medicine, Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Precision Vaccine Program, Boston Children’s Hospital, Boston, Massachusetts, United States of America

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