FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K/Akt signaling and inhibiting apoptosis

• Arvind Ponnusamy ,

  Contributed equally to this work with: Arvind Ponnusamy, Smeeta Sinha

  Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

  Current address: Renal Department, Royal Preston Hospital, Preston, United Kingdom.

  Affiliations Vascular Research Group, Salford Royal NHS Foundation Trust, Salford, United Kingdom, Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom

  ⨯
• Smeeta Sinha ,

  Contributed equally to this work with: Arvind Ponnusamy, Smeeta Sinha

  Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Vascular Research Group, Salford Royal NHS Foundation Trust, Salford, United Kingdom, Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom

  ⨯
• Gareth D. Hyde,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Current address: National Heart and Lung Institute, Imperial College, London, United Kingdom.

  Affiliation Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom

  ⨯
• Samantha J. Borland,

  Roles Formal analysis, Writing – review & editing

  Affiliation Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom

  http://orcid.org/0000-0001-7358-5829

  ⨯
• Rebecca F. Taylor,

  Roles Formal analysis, Investigation

  Affiliation Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom

  http://orcid.org/0000-0003-4033-3793

  ⨯
• Emma Pond,

  Roles Formal analysis, Investigation

  Current address: Cancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.

  Affiliation Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom

  ⨯
• Heather J. Eyre,

  Roles Formal analysis, Investigation

  Current address: Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom.

  Affiliation Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom

  http://orcid.org/0000-0001-9932-3595

  ⨯
• Colette A. Inkson,

  Roles Methodology

  Current address: Manchester Fungal Infection Group, School of Biological Sciences, Faculty of Biology Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom.

  Affiliation Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom

  ⨯
• Andrew Gilmore,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation Division of Cancer Studies & Wellcome Trust Centre for Cell-Matrix Research, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom

  ⨯
• Nick Ashton,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom

  ⨯
• Philip A. Kalra,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Vascular Research Group, Salford Royal NHS Foundation Trust, Salford, United Kingdom, Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom

  ⨯
• Ann E. Canfield

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: ann.canfield@manchester.ac.uk

  Affiliation Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom

  http://orcid.org/0000-0002-8983-5674

  ⨯