Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus

Kelly A. Hamilton; Yue Wang; Sophia M. Raefsky; Sean Berkowitz; Ryan Spangler; Caitlin N. Suire; Simonetta Camandola; Robert H. Lipsky; Mark P. Mattson

doi:10.1371/journal.pone.0196223

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Open Access

Peer-reviewed

Research Article

Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus

Kelly A. Hamilton,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliations Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland, United States of America, Krasnow Institute for Advanced Study, George Mason University, Fairfax, Virginia, United States of America
⨯
Yue Wang,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland, United States of America
⨯
Sophia M. Raefsky,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland, United States of America
⨯
Sean Berkowitz,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland, United States of America
⨯
Ryan Spangler,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland, United States of America
⨯
Caitlin N. Suire,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland, United States of America
⨯
Simonetta Camandola,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland, United States of America
⨯
Robert H. Lipsky ,

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: Robert.Lipsky@inova.org

Affiliations Krasnow Institute for Advanced Study, George Mason University, Fairfax, Virginia, United States of America, Department of Neurosciences, Inova Health System, Falls Church, Virginia, United States of America
⨯
Mark P. Mattson

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland, United States of America
⨯

Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus

Kelly A. Hamilton,
Yue Wang,
Sophia M. Raefsky,
Sean Berkowitz,
Ryan Spangler,
Caitlin N. Suire,
Simonetta Camandola,
Robert H. Lipsky,
Mark P. Mattson

Published: May 1, 2018
https://doi.org/10.1371/journal.pone.0196223

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Hippocampus
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Gene expression
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Synaptic plasticity
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Insulin
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Mice
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Neuronal plasticity
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