Inactivation of bpsl1039-1040 ATP-binding cassette transporter reduces intracellular survival in macrophages, biofilm formation and virulence in the murine model of Burkholderia pseudomallei infection

Peechanika Pinweha; Pornpan Pumirat; Jon Cuccui; Niramol Jitprasutwit; Veerachat Muangsombut; Varintip Srinon; Usa Boonyuen; Parameth Thiennimitr; Paiboon Vattanaviboon; Felipe Cia; Sam Willcocks; Gregory J. Bancroft; Brendan W. Wren; Sunee Korbsrisate

doi:10.1371/journal.pone.0196202

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Open Access

Peer-reviewed

Research Article

Inactivation of bpsl1039-1040 ATP-binding cassette transporter reduces intracellular survival in macrophages, biofilm formation and virulence in the murine model of Burkholderia pseudomallei infection

Peechanika Pinweha ,

Contributed equally to this work with: Peechanika Pinweha, Pornpan Pumirat

Roles Investigation, Writing – original draft

Affiliation Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
⨯
Pornpan Pumirat ,

Contributed equally to this work with: Peechanika Pinweha, Pornpan Pumirat

Roles Investigation, Writing – original draft

Affiliation Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
⨯
Jon Cuccui,

Roles Conceptualization, Investigation, Supervision, Writing – review & editing

Affiliation Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Niramol Jitprasutwit,

Roles Investigation

Affiliation Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
⨯
Veerachat Muangsombut,

Roles Investigation

Affiliation Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
⨯
Varintip Srinon,

Roles Investigation

Affiliation Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
⨯
Usa Boonyuen,

Roles Investigation

Affiliation Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
⨯
Parameth Thiennimitr,

Roles Investigation, Resources

Affiliation Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
⨯
Paiboon Vattanaviboon,

Roles Resources

Affiliation Laboratory of Biotechnology, Chulabhorn Research Institute, Bangkok, Thailand
⨯
Felipe Cia,

Roles Investigation

Affiliation Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Sam Willcocks,

Roles Investigation

Affiliation Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Gregory J. Bancroft,

Roles Resources, Writing – review & editing

Affiliation Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Brendan W. Wren ,

Roles Supervision, Writing – review & editing

* E-mail: brendan.wren@lshtm.ac.uk (BWW); sunee.kor@mahidol.ac.th (SK)

Affiliation Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Sunee Korbsrisate

Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

* E-mail: brendan.wren@lshtm.ac.uk (BWW); sunee.kor@mahidol.ac.th (SK)

Affiliation Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

http://orcid.org/0000-0003-4732-0733

⨯

Inactivation of bpsl1039-1040 ATP-binding cassette transporter reduces intracellular survival in macrophages, biofilm formation and virulence in the murine model of Burkholderia pseudomallei infection

Peechanika Pinweha,
Pornpan Pumirat,
Jon Cuccui,
Niramol Jitprasutwit,
Veerachat Muangsombut,
Varintip Srinon,
Usa Boonyuen,
Parameth Thiennimitr,
Paiboon Vattanaviboon,
Felipe Cia

Published: May 17, 2018
https://doi.org/10.1371/journal.pone.0196202

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