β1 integrins mediate the BMP2 dependent transcriptional control of osteoblast differentiation and osteogenesis

Molly Brunner; Noémie Mandier; Thierry Gautier; Genevieve Chevalier; Anne-Sophie Ribba; Philippe Guardiola; Marc R. Block; Daniel Bouvard

doi:10.1371/journal.pone.0196021

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Open Access

Peer-reviewed

Research Article

β1 integrins mediate the BMP2 dependent transcriptional control of osteoblast differentiation and osteogenesis

Molly Brunner,

Roles Conceptualization, Formal analysis, Investigation, Validation, Writing – review & editing

Affiliation Centre de Recherche INSERM 1209, CNRS 5309, Institute for Advanced Bioscience; Université Grenoble Alpes, Grenoble, France
⨯
Noémie Mandier,

Roles Investigation, Validation

Affiliation Centre de Recherche INSERM 1209, CNRS 5309, Institute for Advanced Bioscience; Université Grenoble Alpes, Grenoble, France
⨯
Thierry Gautier,

Roles Formal analysis, Writing – review & editing

Affiliation Centre de Recherche INSERM 1209, CNRS 5309, Institute for Advanced Bioscience; Université Grenoble Alpes, Grenoble, France
⨯
Genevieve Chevalier,

Roles Investigation

Affiliation Centre de Recherche INSERM 1209, CNRS 5309, Institute for Advanced Bioscience; Université Grenoble Alpes, Grenoble, France
⨯
Anne-Sophie Ribba,

Roles Resources

Affiliation Centre de Recherche INSERM 1209, CNRS 5309, Institute for Advanced Bioscience; Université Grenoble Alpes, Grenoble, France
⨯
Philippe Guardiola,

Roles Data curation, Investigation, Validation

Affiliation Centre Hospitalier Universitaire and University of Angers, SNP Plateform, Institute for Biological Health, Transcriptome and Epigenomic, Angers, France
⨯
Marc R. Block,

Roles Formal analysis, Investigation, Validation, Writing – original draft, Writing – review & editing

Affiliation Centre de Recherche INSERM 1209, CNRS 5309, Institute for Advanced Bioscience; Université Grenoble Alpes, Grenoble, France
⨯
Daniel Bouvard

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: daniel.bouvard@univ-grenoble-alpes.fr

Affiliation Centre de Recherche INSERM 1209, CNRS 5309, Institute for Advanced Bioscience; Université Grenoble Alpes, Grenoble, France

http://orcid.org/0000-0002-0845-6681

⨯

β1 integrins mediate the BMP2 dependent transcriptional control of osteoblast differentiation and osteogenesis

Molly Brunner,
Noémie Mandier,
Thierry Gautier,
Genevieve Chevalier,
Anne-Sophie Ribba,
Philippe Guardiola,
Marc R. Block,
Daniel Bouvard

Published: April 20, 2018
https://doi.org/10.1371/journal.pone.0196021

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Integrins
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Osteoblasts
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Osteoblast differentiation
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Phosphorylation
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Collagens
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SMAD signaling
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Extracellular matrix
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Bone development
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