Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib

• Marcus J. G. W. Ladds ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: marcus.ladds@ki.se (MJGWL); sonia.lain@ki.se (SL)

  Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

  http://orcid.org/0000-0002-9894-0169

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• Andrés Pastor-Fernández,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

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• Gergana Popova,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

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• Ingeborg M. M. van Leeuwen,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

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• Kai Er Eng,

  Roles Data curation, Investigation

  Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

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• Catherine J. Drummond,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

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• Lars Johansson,

  Roles Formal analysis, Investigation, Resources, Writing – review & editing

  Affiliation Chemical Biology Consortium Sweden, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Karolinska Institutet, Stockholm, Sweden

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• Richard Svensson,

  Roles Data curation, Resources, Software

  Affiliation Department of Pharmacy, Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Uppsala University, Uppsala, Sweden

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• Nicholas J. Westwood,

  Roles Data curation, Formal analysis, Funding acquisition, Methodology, Resources, Writing – review & editing

  Affiliation School of Chemistry and Biomedical Science Research Complex, University of St. Andrews and EaStCHEM, St Andrews, Fife, Scotland, United Kingdom

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• Anna R. McCarthy †,

  † Deceased.

  Roles Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

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• Fredrik Tholander,

  Roles Resources, Software, Writing – review & editing

  Affiliation Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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• Mihaela Popa,

  Roles Resources

  Affiliation Department of Clinical Science, University of Bergen, Bergen, Norway

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• David P. Lane,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

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• Emmet McCormack,

  Roles Resources, Writing – review & editing

  Affiliations Department of Clinical Science, University of Bergen, Bergen, Norway, Department of Internal Medicine, Hematology Section, Haukeland University Hospital, Bergen, Norway

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• Gerald M. McInerney,

  Roles Conceptualization, Data curation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

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• Ravi Bhatia,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Department of Hematology and Oncology, University of Alabama, Birmingham, Alabama, United States of America

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•  [ ... ],
• Sonia Laín

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: marcus.ladds@ki.se (MJGWL); sonia.lain@ki.se (SL)

  Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

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