Adipose-derived mesenchymal stem cells (AdMSC) for the treatment of secondary-progressive multiple sclerosis: A triple blinded, placebo controlled, randomized phase I/II safety and feasibility study

• Oscar Fernández ,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: oscar.fernandez.sspa@gmail.com

  Affiliation Unidad de Gestión Clínica de Neurociencias Clínicas, Servicio de Neurología y Servicio de Neurofisiología, Hospital Regional Universitario, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Malaga, Spain

  http://orcid.org/0000-0003-3696-789X

  ⨯
• Guillermo Izquierdo,

  Roles Investigation, Writing – review & editing

  Affiliation Servicio de Neurología, Hospital Universitario Virgen Macarena, University of Seville, Seville, Spain

  ⨯
• Victoria Fernández,

  Roles Data curation, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Unidad de Gestión Clínica de Neurociencias Clínicas, Servicio de Neurología y Servicio de Neurofisiología, Hospital Regional Universitario, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Malaga, Spain

  ⨯
• Laura Leyva,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Unidad de Gestión Clínica de Neurociencias Clínicas, Servicio de Neurología y Servicio de Neurofisiología, Hospital Regional Universitario, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Malaga, Spain

  ⨯
• Virginia Reyes,

  Roles Investigation, Writing – review & editing

  Affiliation Unidad de Gestión Clínica de Neurociencias Clínicas, Servicio de Neurología y Servicio de Neurofisiología, Hospital Regional Universitario, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Malaga, Spain

  ⨯
• Miguel Guerrero,

  Roles Investigation, Writing – review & editing

  Affiliation Unidad de Gestión Clínica de Neurociencias Clínicas, Servicio de Neurología y Servicio de Neurofisiología, Hospital Regional Universitario, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Malaga, Spain

  ⨯
• Antonio León,

  Roles Investigation, Writing – review & editing

  Affiliation Unidad de Gestión Clínica de Neurociencias Clínicas, Servicio de Neurología y Servicio de Neurofisiología, Hospital Regional Universitario, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Malaga, Spain

  ⨯
• Carlos Arnaiz,

  Roles Investigation, Writing – review & editing

  Affiliation Unidad de Gestión Clínica de Neurociencias Clínicas, Servicio de Neurología y Servicio de Neurofisiología, Hospital Regional Universitario, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Malaga, Spain

  ⨯
• Guillermo Navarro,

  Roles Investigation, Writing – review & editing

  Affiliation Servicio de Neurología, Hospital Universitario Virgen Macarena, University of Seville, Seville, Spain

  ⨯
• Maria Dolores Páramo,

  Roles Investigation, Writing – review & editing

  Affiliation Servicio de Neurología, Hospital Universitario Virgen Macarena, University of Seville, Seville, Spain

  ⨯
• Antonio De la Cuesta,

  Roles Investigation, Writing – review & editing

  Affiliation Servicio de Neurología, Hospital Universitario Virgen Macarena, University of Seville, Seville, Spain

  ⨯
• Bernat Soria,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation CABIMER (Andalusian Molecular Biology and Regenerative Medicine Centre), Seville, Spain

  ⨯
• Abdelkrim Hmadcha,

  Roles Investigation, Writing – review & editing

  Affiliation CABIMER (Andalusian Molecular Biology and Regenerative Medicine Centre), Seville, Spain

  ⨯
• David Pozo,

  Roles Investigation

  Affiliation CABIMER (Andalusian Molecular Biology and Regenerative Medicine Centre), Seville, Spain

  ⨯
• Rafael Fernandez-Montesinos,

  Roles Investigation, Writing – review & editing

  Affiliation CABIMER (Andalusian Molecular Biology and Regenerative Medicine Centre), Seville, Spain

  ⨯
• Maria Leal,

  Roles Investigation, Writing – review & editing

  Affiliation CABIMER (Andalusian Molecular Biology and Regenerative Medicine Centre), Seville, Spain

  ⨯
• Itziar Ochotorena,

  Roles Investigation, Writing – review & editing

  Affiliation CABIMER (Andalusian Molecular Biology and Regenerative Medicine Centre), Seville, Spain

  ⨯
• Patricia Gálvez,

  Roles Investigation, Writing – review & editing

  Affiliation CABIMER (Andalusian Molecular Biology and Regenerative Medicine Centre), Seville, Spain

  ⨯
• Maria Angeles Geniz,

  Roles Investigation, Writing – review & editing

  Affiliation Servicio de Neurología, Hospital Universitario Virgen Macarena, University of Seville, Seville, Spain

  ⨯
• Francisco Javier Barón,

  Roles Formal analysis

  Affiliations Unidad de Gestión Clínica de Neurociencias Clínicas, Servicio de Neurología y Servicio de Neurofisiología, Hospital Regional Universitario, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Malaga, Spain, Public Health Department, University of Malaga, Malaga, SPAIN

  ⨯
• Rosario Mata,

  Roles Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Andalusian Initiative for Advanced Therapies, Junta de Andalucía, Seville, Spain

  ⨯
• Cristina Medina,

  Roles Formal analysis, Writing – review & editing

  Affiliation Andalusian Initiative for Advanced Therapies, Junta de Andalucía, Seville, Spain

  ⨯
• Carlos Caparrós-Escudero,

  Roles Investigation, Writing – review & editing

  Affiliation Servicio de Radiodiagnóstico, Hospital Universitario Virgen Macarena, University of Seville, Seville, Spain

  ⨯
• Ana Cardesa,

  Roles Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Andalusian Initiative for Advanced Therapies, Junta de Andalucía, Seville, Spain

  ⨯
• Natividad Cuende,

  Roles Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Andalusian Initiative for Advanced Therapies, Junta de Andalucía, Seville, Spain

  ⨯
•  [ ... ],
• on behalf of the Research Group Study EudraCT 2008-004015-35

  ¶Complete membership of the Research Group Study EudraCT 2008-004015-35 can be found in the Acknowledgments.

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