Early postnatal soluble FGFR3 therapy prevents the atypical development of obesity in achondroplasia

Celine Saint-Laurent; Stephanie Garcia; Vincent Sarrazy; Karine Dumas; Florence Authier; Sophie Sore; Albert Tran; Philippe Gual; Isabelle Gennero; Jean-Pierre Salles; Elvire Gouze

doi:10.1371/journal.pone.0195876

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Open Access

Peer-reviewed

Research Article

Early postnatal soluble FGFR3 therapy prevents the atypical development of obesity in achondroplasia

Celine Saint-Laurent ,

Contributed equally to this work with: Celine Saint-Laurent, Stephanie Garcia

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations Université Côte d’Azur, CNRS, Inserm, iBV, Nice, France, Université Côte d’Azur, CHU, Inserm, C3M, Nice, France
⨯
Stephanie Garcia ,

Contributed equally to this work with: Celine Saint-Laurent, Stephanie Garcia

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Université Côte d’Azur, CHU, Inserm, C3M, Nice, France
⨯
Vincent Sarrazy,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Université Côte d’Azur, CHU, Inserm, C3M, Nice, France
⨯
Karine Dumas,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Université Côte d’Azur, CHU, Inserm, C3M, Nice, France
⨯
Florence Authier,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Université Côte d’Azur, CNRS, Inserm, iBV, Nice, France
⨯
Sophie Sore,

Roles Data curation

Affiliation Université Côte d’Azur, CNRS, Inserm, iBV, Nice, France
⨯
Albert Tran,

Roles Writing – review & editing

Affiliation Université Côte d’Azur, CHU, Inserm, C3M, Nice, France
⨯
Philippe Gual,

Roles Writing – review & editing

Affiliation Université Côte d’Azur, CHU, Inserm, C3M, Nice, France
⨯
Isabelle Gennero,

Roles Data curation, Formal analysis, Writing – original draft

Affiliations University of Paul Sabatier Toulouse III, Inserm, CPTP, Toulouse, France, Biochemistry Laboratory, Institut Federatif de Biologie, Toulouse University hospital, Toulouse, France
⨯
Jean-Pierre Salles,

Roles Conceptualization, Investigation, Supervision, Writing – review & editing

Affiliations University of Paul Sabatier Toulouse III, Inserm, CPTP, Toulouse, France, Endocrine, Bone Diseases, and Genetics Unit, Children's Hospital, Toulouse University Hospital, Toulouse, France
⨯
Elvire Gouze

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: elvire.gouze@inserm.fr

Affiliations Université Côte d’Azur, CNRS, Inserm, iBV, Nice, France, Université Côte d’Azur, CHU, Inserm, C3M, Nice, France
⨯

Early postnatal soluble FGFR3 therapy prevents the atypical development of obesity in achondroplasia

Celine Saint-Laurent,
Stephanie Garcia,
Vincent Sarrazy,
Karine Dumas,
Florence Authier,
Sophie Sore,
Albert Tran,
Philippe Gual,
Isabelle Gennero,
Jean-Pierre Salles

Published: April 13, 2018
https://doi.org/10.1371/journal.pone.0195876

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Achondroplasia
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Obesity
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Genetically modified animals
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Adipose tissue
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Insulin
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