Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes

Jonathan Baker; Adrian M. D. Falconer; David J. Wilkinson; G. Nicholas Europe-Finner; Gary J. Litherland; Andrew D. Rowan

doi:10.1371/journal.pone.0195864

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Open Access

Peer-reviewed

Research Article

Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes

Jonathan Baker,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Current address: Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

Affiliation Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Adrian M. D. Falconer,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
David J. Wilkinson,

Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

Affiliation Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom

http://orcid.org/0000-0002-6262-3575

⨯
G. Nicholas Europe-Finner,

Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Gary J. Litherland,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Supervision, Validation, Writing – review & editing

Current address: School of Science and Sport, University of the West of Scotland, Paisley Campus, Paisley, Scotland

Affiliation Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Andrew D. Rowan

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: drew.rowan@ncl.ac.uk

Affiliation Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom

http://orcid.org/0000-0002-5338-1295

⨯

Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes

Jonathan Baker,
Adrian M. D. Falconer,
David J. Wilkinson,
G. Nicholas Europe-Finner,
Gary J. Litherland,
Andrew D. Rowan

Published: April 13, 2018
https://doi.org/10.1371/journal.pone.0195864

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Chondrocytes
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Phosphorylation
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Small interfering RNA
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Transfection
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Cartilage
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STAT signaling
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Gene silencing
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Protein kinases
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