Functional disruption of the Golgi apparatus protein ARF1 sensitizes MDA-MB-231 breast cancer cells to the antitumor drugs Actinomycin D and Vinblastine through ERK and AKT signaling

Charlotte Luchsinger; Marcelo Aguilar; Patricia V. Burgos; Pamela Ehrenfeld; Gonzalo A. Mardones

doi:10.1371/journal.pone.0195401

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Research Article

Functional disruption of the Golgi apparatus protein ARF1 sensitizes MDA-MB-231 breast cancer cells to the antitumor drugs Actinomycin D and Vinblastine through ERK and AKT signaling

Charlotte Luchsinger ,

Contributed equally to this work with: Charlotte Luchsinger, Marcelo Aguilar

Roles Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations Department of Physiology, School of Medicine, Universidad Austral de Chile, Valdivia, Chile, Center for Interdisciplinary Studies of the Nervous System (CISNe), Universidad Austral de Chile, Valdivia, Chile
⨯
Marcelo Aguilar ,

Contributed equally to this work with: Charlotte Luchsinger, Marcelo Aguilar

Roles Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations Department of Physiology, School of Medicine, Universidad Austral de Chile, Valdivia, Chile, Center for Interdisciplinary Studies of the Nervous System (CISNe), Universidad Austral de Chile, Valdivia, Chile
⨯
Patricia V. Burgos,

Roles Formal analysis, Funding acquisition, Methodology, Supervision, Writing – original draft

Affiliations Department of Physiology, School of Medicine, Universidad Austral de Chile, Valdivia, Chile, Center for Interdisciplinary Studies of the Nervous System (CISNe), Universidad Austral de Chile, Valdivia, Chile, Center for Cell Biology and Biomedicine (CEBICEM), School of Medicine and Science, Universidad San Sebastián, Santiago, Chile, Center for Aging and Regeneration (CARE), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
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Pamela Ehrenfeld,

Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – original draft

Affiliations Center for Interdisciplinary Studies of the Nervous System (CISNe), Universidad Austral de Chile, Valdivia, Chile, Department of Anatomy, Histology and Pathology, School of Medicine, Universidad Austral de Chile, Valdivia, Chile
⨯
Gonzalo A. Mardones

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft

* E-mail: gonzalo.mardones@uach.cl

Affiliations Department of Physiology, School of Medicine, Universidad Austral de Chile, Valdivia, Chile, Center for Interdisciplinary Studies of the Nervous System (CISNe), Universidad Austral de Chile, Valdivia, Chile, Center for Cell Biology and Biomedicine (CEBICEM), School of Medicine and Science, Universidad San Sebastián, Santiago, Chile

http://orcid.org/0000-0001-9390-5893

⨯

Functional disruption of the Golgi apparatus protein ARF1 sensitizes MDA-MB-231 breast cancer cells to the antitumor drugs Actinomycin D and Vinblastine through ERK and AKT signaling

Charlotte Luchsinger,
Marcelo Aguilar,
Patricia V. Burgos,
Pamela Ehrenfeld,
Gonzalo A. Mardones

Published: April 3, 2018
https://doi.org/10.1371/journal.pone.0195401

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Cancer treatment
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Golgi apparatus
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Breast cancer
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Cell disruption
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Apoptosis
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Cell proliferation
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