Applying chlorogenic acid in an alginate scaffold of chondrocytes can improve the repair of damaged articular cartilage

Xin Cheng; Ke Li; Shengsong Xu; Peizhi Li; Yu Yan; Guang Wang; Zachary Berman; Rui Guo; Jianxin Liang; Sira Traore; Xuesong Yang

doi:10.1371/journal.pone.0195326

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Open Access

Peer-reviewed

Research Article

Applying chlorogenic acid in an alginate scaffold of chondrocytes can improve the repair of damaged articular cartilage

Xin Cheng ,

Contributed equally to this work with: Xin Cheng, Ke Li, Shengsong Xu

Roles Conceptualization, Funding acquisition, Project administration, Resources

Affiliation Department of Histology and Embryology, Joint Laboratory for Embryonic Development & Prenatal Medicine, Medical College, Jinan University, Guangzhou, Guangdong, China
⨯
Ke Li ,

Contributed equally to this work with: Xin Cheng, Ke Li, Shengsong Xu

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Histology and Embryology, Joint Laboratory for Embryonic Development & Prenatal Medicine, Medical College, Jinan University, Guangzhou, Guangdong, China
⨯
Shengsong Xu ,

Contributed equally to this work with: Xin Cheng, Ke Li, Shengsong Xu

Roles Investigation, Software

Affiliation Department of Histology and Embryology, Joint Laboratory for Embryonic Development & Prenatal Medicine, Medical College, Jinan University, Guangzhou, Guangdong, China
⨯
Peizhi Li,

Roles Investigation

Affiliation Department of Histology and Embryology, Joint Laboratory for Embryonic Development & Prenatal Medicine, Medical College, Jinan University, Guangzhou, Guangdong, China
⨯
Yu Yan,

Roles Investigation

Affiliation Department of Histology and Embryology, Joint Laboratory for Embryonic Development & Prenatal Medicine, Medical College, Jinan University, Guangzhou, Guangdong, China
⨯
Guang Wang,

Roles Data curation

Affiliation Department of Histology and Embryology, Joint Laboratory for Embryonic Development & Prenatal Medicine, Medical College, Jinan University, Guangzhou, Guangdong, China
⨯
Zachary Berman,

Roles Investigation, Writing – review & editing

Affiliation Department of Radiology, University of California San Diego, San Diego, California, United States of America
⨯
Rui Guo,

Roles Software

Affiliation Department of Histology and Embryology, Joint Laboratory for Embryonic Development & Prenatal Medicine, Medical College, Jinan University, Guangzhou, Guangdong, China
⨯
Jianxin Liang,

Roles Investigation

Affiliation Department of Histology and Embryology, Joint Laboratory for Embryonic Development & Prenatal Medicine, Medical College, Jinan University, Guangzhou, Guangdong, China
⨯
Sira Traore,

Roles Data curation

Affiliation Department of Histology and Embryology, Joint Laboratory for Embryonic Development & Prenatal Medicine, Medical College, Jinan University, Guangzhou, Guangdong, China
⨯
Xuesong Yang

Roles Conceptualization, Writing – original draft

* E-mail: yang_xuesong@126.com

Affiliations Department of Histology and Embryology, Joint Laboratory for Embryonic Development & Prenatal Medicine, Medical College, Jinan University, Guangzhou, Guangdong, China, Key Laboratory for Regenerative Medicine of the Ministry of Education, Jinan University, Guangzhou, Guangdong, China

http://orcid.org/0000-0002-2537-5752

⨯

Applying chlorogenic acid in an alginate scaffold of chondrocytes can improve the repair of damaged articular cartilage

Xin Cheng,
Ke Li,
Shengsong Xu,
Peizhi Li,
Yu Yan,
Guang Wang,
Zachary Berman,
Rui Guo,
Jianxin Liang,
Sira Traore

Published: April 5, 2018
https://doi.org/10.1371/journal.pone.0195326

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Chondrocytes
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Articular cartilage
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Cartilage
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Cell staining
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DAPI staining
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Fibrosis
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