A novel calcimimetic agent, evocalcet (MT-4580/KHK7580), suppresses the parathyroid cell function with little effect on the gastrointestinal tract or CYP isozymes in vivo and in vitro

• Takehisa Kawata,

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Nephrology Research Laboratories, Nephrology R&D Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., Shizuoka, Japan

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• Shin Tokunaga,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Nephrology Research Laboratories, Nephrology R&D Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., Shizuoka, Japan

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• Miki Murai,

  Roles Data curation, Formal analysis, Visualization

  Affiliation Research Core Function Laboratories, Research Functions Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., Shizuoka, Japan

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• Nami Masuda,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Takasaki Plant, Production Division, Kyowa Hakko Kirin Co., Ltd., Gunma, Japan

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• Waka Haruyama,

  Roles Data curation, Formal analysis, Investigation, Visualization

  Affiliation Nephrology Research Laboratories, Nephrology R&D Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., Shizuoka, Japan

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• Youji Shoukei,

  Roles Data curation

  Affiliation Research Core Function Laboratories, Research Functions Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., Shizuoka, Japan

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• Yutaka Hisada,

  Roles Conceptualization, Data curation, Investigation, Methodology

  Affiliation Research Unit, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation., Kanagawa, Japan

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• Tetsuya Yanagida,

  Roles Conceptualization, Data curation, Investigation, Methodology

  Affiliation Research Unit, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation., Kanagawa, Japan

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• Hiroshi Miyazaki,

  Roles Conceptualization

  Affiliation Research Unit, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation., Kanagawa, Japan

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• Michihito Wada,

  Roles Conceptualization, Project administration

  Affiliation Medical Affairs Department, Kyowa Hakko Kirin Co., Ltd., Tokyo, Japan

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• Tadao Akizawa,

  Roles Supervision, Writing – original draft, Writing – review & editing

  Affiliation Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan

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• Masafumi Fukagawa

  Roles Supervision, Writing – original draft, Writing – review & editing

  * E-mail: fukagawa@tokai-u.jp

  Affiliation Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Kanagawa, Japan

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