Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer

Elizabeth A. Germino; Joseph P. Miller; Lauri Diehl; Carter J. Swanson; Steffen Durinck; Zora Modrusan; Jeffrey H. Miner; Andrey S. Shaw

doi:10.1371/journal.pone.0194998

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Open Access

Peer-reviewed

Research Article

Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer

Elizabeth A. Germino,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Research Biology, Genentech, South San Francisco, California, United States of America
⨯
Joseph P. Miller,

Roles Investigation

Affiliation Division of Nephrology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Lauri Diehl,

Roles Investigation

Affiliation Department of Pathology, Genentech, South San Francisco, California, United States of America
⨯
Carter J. Swanson,

Roles Investigation

Affiliation Department of Research Biology, Genentech, South San Francisco, California, United States of America

http://orcid.org/0000-0001-6697-9475

⨯
Steffen Durinck,

Roles Investigation

Affiliations Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, California, United States of America, Department of Molecular Biology, Genentech, South San Francisco, California, United States of America
⨯
Zora Modrusan,

Roles Investigation

Affiliation Department of Molecular Biology, Genentech, South San Francisco, California, United States of America
⨯
Jeffrey H. Miner,

Roles Data curation, Investigation

Affiliation Division of Nephrology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Andrey S. Shaw

Roles Conceptualization, Investigation, Supervision, Writing – review & editing

* E-mail: shaw.andrey@gene.com

Affiliations Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Research Biology, Genentech, South San Francisco, California, United States of America

http://orcid.org/0000-0001-5685-0272

⨯

Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer

Elizabeth A. Germino,
Joseph P. Miller,
Lauri Diehl,
Carter J. Swanson,
Steffen Durinck,
Zora Modrusan,
Jeffrey H. Miner,
Andrey S. Shaw

Published: March 29, 2018
https://doi.org/10.1371/journal.pone.0194998

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Mouse models
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Breast cancer
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Heterozygosity
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