Pre-treatment tumour perfusion parameters and initial RECIST response do not predict long-term survival outcomes for patients with head and neck squamous cell carcinoma treated with induction chemotherapy

Natalie M. Lowe; Lucy E. Kershaw; Jonathan M. Bernstein; Stephanie B. Withey; Kathleen Mais; Jarrod J. Homer; Nicholas J. Slevin; Suzanne C. Bonington; Bernadette M. Carrington; Catharine M. West

doi:10.1371/journal.pone.0194841

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Open Access

Peer-reviewed

Research Article

Pre-treatment tumour perfusion parameters and initial RECIST response do not predict long-term survival outcomes for patients with head and neck squamous cell carcinoma treated with induction chemotherapy

Natalie M. Lowe,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliation Division of Cancer Sciences, Manchester Academic Health Science Centre, University of Manchester, The Christie NHS Foundation Trust, Manchester, United Kingdom

http://orcid.org/0000-0002-0348-5184

⨯
Lucy E. Kershaw,

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliations Division of Cancer Sciences, Manchester Academic Health Science Centre, University of Manchester, The Christie NHS Foundation Trust, Manchester, United Kingdom, Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, United Kingdom
⨯
Jonathan M. Bernstein,

Roles Data curation, Investigation, Methodology, Project administration, Validation, Writing – review & editing

Affiliations Division of Cancer Sciences, Manchester Academic Health Science Centre, University of Manchester, The Christie NHS Foundation Trust, Manchester, United Kingdom, Department of Otolaryngology—Head & Neck Surgery, The Royal Marsden NHS Foundation Trust, London, United Kingdom
⨯
Stephanie B. Withey,

Roles Formal analysis

Affiliation Medical Physics, University Hospitals Birmingham, Birmingham, United Kingdom
⨯
Kathleen Mais,

Roles Investigation

Affiliation Head and Neck Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom
⨯
Jarrod J. Homer,

Roles Conceptualization, Writing – review & editing

Affiliations Division of Cancer Sciences, Manchester Academic Health Science Centre, University of Manchester, The Christie NHS Foundation Trust, Manchester, United Kingdom, University Department of Otolaryngology—Head & Neck Surgery, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom
⨯
Nicholas J. Slevin,

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Division of Cancer Sciences, Manchester Academic Health Science Centre, University of Manchester, The Christie NHS Foundation Trust, Manchester, United Kingdom, Head and Neck Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom
⨯
Suzanne C. Bonington,

Roles Conceptualization, Formal analysis, Methodology, Resources, Validation, Writing – review & editing

Affiliation Department of Radiology, The Christie NHS Foundation Trust, Manchester, United Kingdom
⨯
Bernadette M. Carrington,

Roles Conceptualization, Formal analysis, Methodology, Project administration, Validation, Writing – review & editing

Affiliation Department of Radiology, The Christie NHS Foundation Trust, Manchester, United Kingdom
⨯
Catharine M. West

Roles Conceptualization, Methodology, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: Catharine.West@manchester.ac.uk

Affiliations Division of Cancer Sciences, Manchester Academic Health Science Centre, University of Manchester, The Christie NHS Foundation Trust, Manchester, United Kingdom, NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom
⨯

Pre-treatment tumour perfusion parameters and initial RECIST response do not predict long-term survival outcomes for patients with head and neck squamous cell carcinoma treated with induction chemotherapy

Natalie M. Lowe,
Lucy E. Kershaw,
Jonathan M. Bernstein,
Stephanie B. Withey,
Kathleen Mais,
Jarrod J. Homer,
Nicholas J. Slevin,
Suzanne C. Bonington,
Bernadette M. Carrington,
Catharine M. West

Published: March 28, 2018
https://doi.org/10.1371/journal.pone.0194841

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Cancer treatment
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Head and neck cancers
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Head and neck squamous cell carcinoma
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Head and neck tumors
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