Clinical endpoints in the controlled human challenge model for Shigella: A call for standardization and the development of a disease severity score

• Chad K. Porter ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: chad.k.porter2.civ@mail.mil

  Affiliation Enteric Disease Department, Infectious Disease Directorate, Naval Medical Research Center, Silver Spring, MD, United States of America

  http://orcid.org/0000-0001-7258-1690

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• Amanda Lynen,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Enteric Disease Department, Infectious Disease Directorate, Naval Medical Research Center, Silver Spring, MD, United States of America

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• Mark S. Riddle,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Enteric Disease Department, Infectious Disease Directorate, Naval Medical Research Center, Silver Spring, MD, United States of America

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• Kawsar Talaat,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States of America

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• David Sack,

  Roles Conceptualization, Writing – review & editing

  Affiliation Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States of America

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• Ramiro L. Gutiérrez,

  Roles Conceptualization, Writing – review & editing

  Affiliation Enteric Disease Department, Infectious Disease Directorate, Naval Medical Research Center, Silver Spring, MD, United States of America

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• Robin McKenzie,

  Roles Investigation, Writing – review & editing

  Affiliation School of Medicine, Johns Hopkins University, Baltimore, MD, United States of America

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• Barbara DeNearing,

  Roles Investigation, Writing – review & editing

  Affiliation Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States of America

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• Brittany Feijoo,

  Roles Writing – review & editing

  Affiliation Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States of America

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• Robert W. Kaminski,

  Roles Conceptualization, Writing – review & editing

  Affiliation Department of Enteric Infections, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America

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• David N. Taylor,

  Roles Investigation, Writing – review & editing

  Affiliation Drug Development Global Program, PATH, Seattle, WA, United States of America

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• Beth D. Kirkpatrick,

  Roles Investigation, Writing – review & editing

  Affiliation University of Vermont College of Medicine, Vaccine Testing Center, Department of Medicine, Burlington, VT, United States of America

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• A. Louis Bourgeois

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliations Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States of America, Enteric Vaccine Initiative, PATH, Washington, DC, United States of America

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