Generation and characterization of a bivalent protein boost for future clinical trials: HIV-1 subtypes CR01_AE and B gp120 antigens with a potent adjuvant

• Yingxia Wen ,

  Contributed equally to this work with: Yingxia Wen, Hung V. Trinh

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Seqirus, a CSL Company, Cambridge, MA, United States of America

  Affiliation Novartis Vaccines and Diagnostics, Cambridge, MA, United States of America

  ⨯
• Hung V. Trinh ,

  Contributed equally to this work with: Yingxia Wen, Hung V. Trinh

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America, Henry Jackson Foundation for the Advancement of Military Medicine, Silver Spring, MD, United States of America

  http://orcid.org/0000-0001-8014-9291

  ⨯
• Christine E. Linton,

  Roles Data curation, Formal analysis, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation GSK, Rockville, MD, United States of America

  ⨯
• Chiara Tani,

  Roles Data curation, Formal analysis, Methodology, Resources, Software, Validation, Visualization, Writing – review & editing

  Affiliation GSK, Siena, Italy

  ⨯
• Nathalie Norais,

  Roles Data curation, Formal analysis, Methodology, Resources, Software, Validation, Visualization, Writing – review & editing

  Affiliation GSK, Siena, Italy

  ⨯
• DeeAnn Martinez-Guzman,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliation Novartis Vaccines and Diagnostics, Cambridge, MA, United States of America

  ⨯
• Priyanka Ramesh,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – review & editing

  Current address: Seqirus, a CSL Company, Holly Springs, NC, United States of America

  Affiliation Novartis Vaccines and Diagnostics, Cambridge, MA, United States of America

  ⨯
• Yide Sun,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliation Novartis Vaccines and Diagnostics, Cambridge, MA, United States of America

  ⨯
• Frank Situ,

  Roles Data curation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Novartis Vaccines and Diagnostics, Cambridge, MA, United States of America

  ⨯
• Selen Karaca-Griffin,

  Roles Data curation, Formal analysis, Validation, Writing – review & editing

  Affiliation Novartis Vaccines and Diagnostics, Cambridge, MA, United States of America

  ⨯
• Christopher Hamlin,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliations US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America, Henry Jackson Foundation for the Advancement of Military Medicine, Silver Spring, MD, United States of America

  ⨯
• Sayali Onkar,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliations US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America, Henry Jackson Foundation for the Advancement of Military Medicine, Silver Spring, MD, United States of America

  ⨯
• Sai Tian,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliation GSK, Rockville, MD, United States of America

  ⨯
• Susan Hilt,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliation Novartis Vaccines and Diagnostics, Cambridge, MA, United States of America

  ⨯
• Padma Malyala,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – review & editing

  Current address: Novartis, Cambridge, MA, United States of America

  Affiliation Novartis Vaccines and Diagnostics, Cambridge, MA, United States of America

  ⨯
• Rushit Lodaya,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliation Novartis Vaccines and Diagnostics, Cambridge, MA, United States of America

  ⨯
• Ning Li,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – review & editing

  Current address: EMD Serono, Inc., Rockland, MA, United States of America

  Affiliation GSK, Rockville, MD, United States of America

  ⨯
• Gillis Otten,

  Roles Conceptualization, Formal analysis, Supervision, Validation, Writing – review & editing

  Current address: Seqirus, a CSL Company, Cambridge, MA, United States of America

  Affiliation Novartis Vaccines and Diagnostics, Cambridge, MA, United States of America

  ⨯
• Giuseppe Palladino,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – review & editing

  Current address: Seqirus, a CSL Company, Cambridge, MA, United States of America

  Affiliation Novartis Vaccines and Diagnostics, Cambridge, MA, United States of America

  ⨯
• Kristian Friedrich,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliation GSK, Rockville, MD, United States of America

  ⨯
• Yukti Aggarwal,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliation Novartis Vaccines and Diagnostics, Cambridge, MA, United States of America

  ⨯
• Celia LaBranche,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliation Department of Surgery, Duke University Medical Center, Durham, NC, United States of America

  ⨯
• Ryan Duffy,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliation Duke Human Vaccine Institute, Duke University, Durham, NC, United States of America

  ⨯
• Xiaoying Shen,

  Roles Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Duke Human Vaccine Institute, Duke University, Durham, NC, United States of America

  ⨯
• Georgia D. Tomaras,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Validation, Writing – review & editing

  Affiliations Department of Surgery, Duke University Medical Center, Durham, NC, United States of America, Duke Human Vaccine Institute, Duke University, Durham, NC, United States of America

  ⨯
• David C. Montefiori,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Validation, Writing – review & editing

  Affiliation Department of Surgery, Duke University Medical Center, Durham, NC, United States of America

  ⨯
• William Fulp,

  Roles Methodology, Software, Validation, Visualization, Writing – review & editing

  Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America

  ⨯
• Raphael Gottardo,

  Roles Methodology, Software, Validation, Visualization, Writing – review & editing

  Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America

  ⨯
• Brian Burke,

  Roles Project administration, Writing – review & editing

  Current address: Nektar Therapeutics, San Francisco, CA, United States of America

  Affiliation Novartis Vaccines and Diagnostics, Cambridge, MA, United States of America

  ⨯
• Jeffrey B. Ulmer ,

  Roles Investigation, Project administration, Resources, Validation, Writing – review & editing

  * E-mail: susan.barnett@gatesfoundation.org (SWB); andrea.carfi@valeratx.com (AC); jeffrey.b.ulmer@gsk.com (JBU)

  Affiliation GSK, Rockville, MD, United States of America

  ⨯
• Susan Zolla-Pazner,

  Roles Resources, Validation, Writing – review & editing

  Affiliation Icahn School of Medicine at Mount Sinai, New York, NY, United States of America

  ⨯
• Hua-Xin Liao,

  Roles Resources, Validation, Writing – review & editing

  Affiliations Duke Human Vaccine Institute, Duke University, Durham, NC, United States of America, Biomedine Institute, College of Life Science, Jinan University, Guangzhou, China

  ⨯
• Barton F. Haynes,

  Roles Conceptualization, Resources, Validation, Writing – review & editing

  Affiliation Duke Human Vaccine Institute, Duke University, Durham, NC, United States of America

  ⨯
• Nelson L. Michael,

  Roles Conceptualization, Resources, Validation, Writing – review & editing

  Affiliation US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America

  ⨯
• Jerome H. Kim,

  Roles Conceptualization, Resources, Validation, Writing – review & editing

  Current address: International Vaccine Institute, Seoul, Republic of Korea

  Affiliation US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America

  ⨯
• Mangala Rao,

  Roles Data curation, Formal analysis, Methodology, Resources, Supervision, Validation, Writing – review & editing

  Affiliation US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America

  ⨯
• Robert J. O’Connell,

  Roles Conceptualization, Investigation, Validation, Writing – review & editing

  Affiliations US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand

  ⨯
• Andrea Carfi ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: susan.barnett@gatesfoundation.org (SWB); andrea.carfi@valeratx.com (AC); jeffrey.b.ulmer@gsk.com (JBU)

  Current address: Valera, a Moderna Venture, Cambridge, MA, United States of America

  Affiliation GSK, Rockville, MD, United States of America

  ⨯
•  [ ... ],
• Susan W. Barnett

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: susan.barnett@gatesfoundation.org (SWB); andrea.carfi@valeratx.com (AC); jeffrey.b.ulmer@gsk.com (JBU)

  Current address: Bill & Melinda Gates Foundation, Seattle, WA, United States of America

  Affiliation GSK, Rockville, MD, United States of America

  ⨯
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