HIV induces production of IL-18 from intestinal epithelial cells that increases intestinal permeability and microbial translocation

Ossama Allam; Suzanne Samarani; Vikram Mehraj; Mohammad-Ali Jenabian; Cecile Tremblay; Jean-Pierre Routy; Devendra Amre; Ali Ahmad

doi:10.1371/journal.pone.0194185

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Open Access

Peer-reviewed

Research Article

HIV induces production of IL-18 from intestinal epithelial cells that increases intestinal permeability and microbial translocation

Ossama Allam,

Roles Data curation, Formal analysis, Investigation, Writing – original draft

Affiliation Laboratory of Innate Immunity, CHU Ste-Justine Research Center/Department of Microbiology, Infectious Diseases & Immunology, University of Montreal, Montreal, Québec, Canada
⨯
Suzanne Samarani,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Laboratory of Innate Immunity, CHU Ste-Justine Research Center/Department of Microbiology, Infectious Diseases & Immunology, University of Montreal, Montreal, Québec, Canada
⨯
Vikram Mehraj,

Roles Methodology, Resources, Writing – review & editing

Affiliation Division of Hematology & Chronic Viral Illness Service, McGill University, Montreal, Québec, Canada
⨯
Mohammad-Ali Jenabian,

Roles Data curation, Methodology, Writing – review & editing

Affiliation Department of Biological Sciences, UQAM, Montreal, Québec, Canada
⨯
Cecile Tremblay,

Roles Resources, Writing – review & editing

Affiliation CHUM/ Department of Microbiology, Infectious Diseases & Immunology, University of Montreal, Montreal, Québec, Canada
⨯
Jean-Pierre Routy,

Roles Resources, Writing – review & editing

Affiliation Division of Hematology & Chronic Viral Illness Service, McGill University, Montreal, Québec, Canada
⨯
Devendra Amre,

Roles Formal analysis, Software, Writing – review & editing

Affiliation CHU Ste-Justine Research Center/Department of Pediatrics, University of Montreal, Montreal, Québec, Canada
⨯
Ali Ahmad

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: ali.ahmad@recherche-ste-justine.qc.ca

Affiliation Laboratory of Innate Immunity, CHU Ste-Justine Research Center/Department of Microbiology, Infectious Diseases & Immunology, University of Montreal, Montreal, Québec, Canada

http://orcid.org/0000-0001-7689-7115

⨯

HIV induces production of IL-18 from intestinal epithelial cells that increases intestinal permeability and microbial translocation

Ossama Allam,
Suzanne Samarani,
Vikram Mehraj,
Mohammad-Ali Jenabian,
Cecile Tremblay,
Jean-Pierre Routy,
Devendra Amre,
Ali Ahmad

Published: March 30, 2018
https://doi.org/10.1371/journal.pone.0194185

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Cytokines
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Gastrointestinal tract
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Permeability
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Epithelial cells
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Cell staining
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HIV
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