Modulation of large dense core vesicle insulin content mediates rhythmic hormone release from pancreatic beta cells over the 24h cycle

• Aurore Quinault,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology

  Affiliation CSGA, AgroSup Dijon, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université de Bourgogne Franche-Comté, 9E Boulevard Jeanne d'Arc, Dijon, France

  ⨯
• Corinne Leloup,

  Roles Funding acquisition, Validation, Writing – review & editing

  Affiliation CSGA, AgroSup Dijon, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université de Bourgogne Franche-Comté, 9E Boulevard Jeanne d'Arc, Dijon, France

  ⨯
• Geoffrey Denwood,

  Roles Investigation, Writing – review & editing

  Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Headington, Oxford, United Kingdom

  ⨯
• Coralie Spiegelhalter,

  Roles Investigation

  Affiliation IGBMC, 1 Rue Laurent Fries, Illkirch-Graffenstaden, France

  ⨯
• Marianne Rodriguez,

  Roles Investigation, Methodology, Resources, Validation

  Affiliation Metabolism Discovery Research Pole of Therapeutical innovation Institut de Recherche Servier, 11 rue des Moulineaux Suresnes, France

  ⨯
• Philippe Lefebvre,

  Roles Data curation, Investigation, Methodology, Validation

  Affiliation European Genomic Institute for Diabetes and UMR 1011 Inserm Université Nord de France-Institut Pasteur de Lille, Boulevard du Professeur Leclerc, Lille, France

  ⨯
• Nadia Messaddeq,

  Roles Investigation, Methodology, Validation

  Affiliation IGBMC, 1 Rue Laurent Fries, Illkirch-Graffenstaden, France

  ⨯
• Quan Zhang,

  Roles Investigation, Methodology, Supervision, Validation

  Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Headington, Oxford, United Kingdom

  ⨯
• Catherine Dacquet,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Validation, Writing – review & editing

  Affiliation Biotechnology and Biomarker Research, Institut de Recherche Servier, 125 Chemin de Ronde, Croissy sur Seine, France

  ⨯
• Luc Pénicaud,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing – review & editing

  Affiliation CSGA, AgroSup Dijon, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université de Bourgogne Franche-Comté, 9E Boulevard Jeanne d'Arc, Dijon, France

  ⨯
• Stephan C. Collins

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: collinss@igbmc.fr

  Affiliations CSGA, AgroSup Dijon, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université de Bourgogne Franche-Comté, 9E Boulevard Jeanne d'Arc, Dijon, France, IGBMC, 1 Rue Laurent Fries, Illkirch-Graffenstaden, France

  http://orcid.org/0000-0002-1533-3380

  ⨯