A pathway-directed positive growth restoration assay to facilitate the discovery of lipid A and fatty acid biosynthesis inhibitors in Acinetobacter baumannii

Daryl L. Richie; Lisha Wang; Helen Chan; Gianfranco De Pascale; David A. Six; Jun-Rong Wei; Charles R. Dean

doi:10.1371/journal.pone.0193851

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Open Access

Peer-reviewed

Research Article

A pathway-directed positive growth restoration assay to facilitate the discovery of lipid A and fatty acid biosynthesis inhibitors in Acinetobacter baumannii

Daryl L. Richie ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: Daryl.Richie@novartis.com

Affiliation Novartis Institutes for BioMedical Research, Emeryville, CA, United States of America

http://orcid.org/0000-0003-0432-5163

⨯
Lisha Wang,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation Novartis Institutes for BioMedical Research, Emeryville, CA, United States of America
⨯
Helen Chan,

Roles Data curation, Formal analysis, Investigation, Validation

Affiliation Novartis Institutes for BioMedical Research, Emeryville, CA, United States of America
⨯
Gianfranco De Pascale,

Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation

Affiliation Novartis Institutes for BioMedical Research, Emeryville, CA, United States of America
⨯
David A. Six,

Roles Formal analysis, Investigation, Project administration, Supervision, Visualization, Writing – review & editing

Affiliation Novartis Institutes for BioMedical Research, Emeryville, CA, United States of America
⨯
Jun-Rong Wei,

Roles Data curation, Formal analysis, Investigation, Methodology, Supervision

Affiliation Novartis Institutes for BioMedical Research, Emeryville, CA, United States of America
⨯
Charles R. Dean

Roles Conceptualization, Formal analysis, Investigation, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliation Novartis Institutes for BioMedical Research, Emeryville, CA, United States of America
⨯

A pathway-directed positive growth restoration assay to facilitate the discovery of lipid A and fatty acid biosynthesis inhibitors in Acinetobacter baumannii

Daryl L. Richie,
Lisha Wang,
Helen Chan,
Gianfranco De Pascale,
David A. Six,
Jun-Rong Wei,
Charles R. Dean

Published: March 5, 2018
https://doi.org/10.1371/journal.pone.0193851

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