Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy

• Olga Ksionda,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Liggins Institute, The University of Auckland, Auckland, New Zealand.

  Affiliation Department of Anatomy, University of California San Francisco, San Francisco, California, United States of America

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• Marsilius Mues,

  Roles Data curation, Formal analysis, Validation, Visualization

  Affiliation Department of Anatomy, University of California San Francisco, San Francisco, California, United States of America

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• Anica M. Wandler,

  Roles Data curation, Formal analysis

  Affiliation Department of Pediatrics, University of California San Francisco, San Francisco, California, United States of America

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• Lisa Donker,

  Roles Data curation, Formal analysis

  Affiliation Department of Anatomy, University of California San Francisco, San Francisco, California, United States of America

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• Milou Tenhagen,

  Roles Data curation, Formal analysis

  Affiliation Department of Anatomy, University of California San Francisco, San Francisco, California, United States of America

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• Jesse Jun,

  Roles Data curation, Formal analysis

  Affiliation Department of Anatomy, University of California San Francisco, San Francisco, California, United States of America

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• Gregory S. Ducker,

  Roles Methodology

  Current address: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

  Affiliation Department of Molecular Pharmacology, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America

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• Ksenia Matlawska-Wasowska,

  Roles Data curation, Formal analysis

  Affiliation Department of Pediatrics, Division of Hematology-Oncology, University of New Mexico, Health Sciences Center, Albuquerque, New Mexico, United States of America

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• Kevin Shannon,

  Roles Funding acquisition, Writing – original draft

  Affiliation Department of Pediatrics, University of California San Francisco, San Francisco, California, United States of America

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• Kevan M. Shokat,

  Roles Funding acquisition, Methodology

  Affiliation Department of Molecular Pharmacology, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America

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• Jeroen P. Roose

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jeroen.roose@ucsf.edu

  Affiliation Department of Anatomy, University of California San Francisco, San Francisco, California, United States of America

  http://orcid.org/0000-0003-4746-2811

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