Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach

Hala O. El-Mesallamy; Hekmat M. El Magdoub; James M. Chapman; Nadia M. Hamdy; Mona F. Schaalan; Lamiaa N. Hammad; Sondra H. Berger

doi:10.1371/journal.pone.0193810

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Open Access

Peer-reviewed

Research Article

Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach

Hala O. El-Mesallamy ,

Roles Conceptualization, Data curation, Investigation, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: hala_elmosalamy@hotmail.com

Affiliation Department of Biochemistry, Faculty of Pharmacy, Ain Sham University, Cairo, Egypt

http://orcid.org/0000-0001-8190-536X

⨯
Hekmat M. El Magdoub,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft

Affiliation Department of Biochemistry, Faculty of Pharmacy, Misr International University, Cairo, Egypt
⨯
James M. Chapman,

Roles Data curation, Formal analysis, Investigation, Software, Visualization

Affiliation Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, United States of America
⨯
Nadia M. Hamdy,

Roles Conceptualization, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Biochemistry, Faculty of Pharmacy, Ain Sham University, Cairo, Egypt
⨯
Mona F. Schaalan,

Roles Conceptualization, Investigation, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Biochemistry, Faculty of Pharmacy, Misr International University, Cairo, Egypt
⨯
Lamiaa N. Hammad,

Roles Conceptualization, Investigation, Project administration, Supervision, Visualization, Writing – original draft

Affiliation Department of Biochemistry, Faculty of Pharmacy, Misr International University, Cairo, Egypt
⨯
Sondra H. Berger

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Resources, Validation, Visualization, Writing – review & editing

Affiliation Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, United States of America
⨯

Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach

Hala O. El-Mesallamy,
Hekmat M. El Magdoub,
James M. Chapman,
Nadia M. Hamdy,
Mona F. Schaalan,
Lamiaa N. Hammad,
Sondra H. Berger

Published: March 14, 2018
https://doi.org/10.1371/journal.pone.0193810

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