The technical reliability and biotemporal stability of cerebrospinal fluid biomarkers for profiling multiple pathophysiologies in Alzheimer’s disease

• Bianca A. Trombetta,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation MGH Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America

  ⨯
• Becky C. Carlyle,

  Roles Writing – original draft, Writing – review & editing

  Affiliation MGH Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America

  http://orcid.org/0000-0003-1491-3217

  ⨯
• Aaron M. Koenig,

  Roles Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliation MGH Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America

  ⨯
• Leslie M. Shaw,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, United States of America

  ⨯
• John Q. Trojanowski,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, United States of America

  ⨯
• David A. Wolk,

  Roles Resources, Writing – review & editing

  Affiliation Penn Memory Center, Department of Neurology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, United States of America

  ⨯
• Joseph J. Locascio,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation MGH Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America

  ⨯
• Steven E. Arnold

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: searnold@mgh.harvard.edu

  Affiliation MGH Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America

  ⨯