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Open Access
Peer-reviewed
Research Article
High content screening of patient-derived cell lines highlights the potential of non-standard chemotherapeutic agents for the treatment of glioblastoma
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Kenny Kwok-Hei Yu ,
Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing
¶‡ These authors are joint senior authors on this work.
Affiliation Brain Tumour Research Group, Stem Cell and Neurotherapies Laboratory, Division of Cell Matrix Biology & Regenerative Medicine, University of Manchester, Manchester, United Kingdom
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Jessica T. Taylor ,
Roles Formal analysis, Investigation, Methodology, Writing – original draft
¶‡ These authors are joint senior authors on this work.
Affiliation Brain Tumour Research Group, Stem Cell and Neurotherapies Laboratory, Division of Cell Matrix Biology & Regenerative Medicine, University of Manchester, Manchester, United Kingdom
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Omar N. Pathmanaban,
Roles Investigation, Methodology
Affiliation Manchester Centre for Clinical Neurosciences, Salford Royal Hospital, Manchester Academic Health Sciences Centre, Salford, United Kingdom
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Amir Saam Youshani,
Roles Formal analysis, Methodology
Affiliation Brain Tumour Research Group, Stem Cell and Neurotherapies Laboratory, Division of Cell Matrix Biology & Regenerative Medicine, University of Manchester, Manchester, United Kingdom
⨯ - Deniz Beyit,
- Joanna Dutko-Gwozdz,
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Roderick Benson,
Roles Data curation, Formal analysis, Investigation, Software
Affiliation Imagen Therapeutics, Manchester, United Kingdom
⨯ - Gareth Griffiths,
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Ian Peers,
Roles Supervision, Writing – review & editing
Affiliation Inferstats Consulting, Alderley Park, Biohub, Cheshire, United Kingdom
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Peter Cueppens,
Roles Supervision, Writing – review & editing
Affiliation Inferstats Consulting, Alderley Park, Biohub, Cheshire, United Kingdom
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Brian A. Telfer,
Roles Resources, Supervision
Affiliation Division of Pharmacy & Optometry, School of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom
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Kaye J. Williams,
Roles Resources, Supervision
Affiliation Division of Pharmacy & Optometry, School of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom
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Catherine McBain,
Roles Supervision, Writing – review & editing
Affiliation Department of Clinical Oncology, The Christie NHS FT, Manchester, United Kingdom
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Ian D. Kamaly-Asl,
Roles Supervision, Writing – review & editing
Affiliations Children’s Brain Tumour Research Network (CBTRN), Royal Manchester Children’s Hospital, Manchester, United Kingdom, Department of Neurosurgery, Royal Manchester Children’s Hospital, Manchester Academic Health Sciences Centre, Manchester, United Kingdom
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Brian W. Bigger
Roles Conceptualization, Supervision, Writing – review & editing
* E-mail: brian.bigger@manchester.ac.uk
Affiliation Brain Tumour Research Group, Stem Cell and Neurotherapies Laboratory, Division of Cell Matrix Biology & Regenerative Medicine, University of Manchester, Manchester, United Kingdom
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High content screening of patient-derived cell lines highlights the potential of non-standard chemotherapeutic agents for the treatment of glioblastoma
- Kenny Kwok-Hei Yu,
- Jessica T. Taylor,
- Omar N. Pathmanaban,
- Amir Saam Youshani,
- Deniz Beyit,
- Joanna Dutko-Gwozdz,
- Roderick Benson,
- Gareth Griffiths,
- Ian Peers,
- Peter Cueppens
- Published: March 2, 2018
- https://doi.org/10.1371/journal.pone.0193694