An analytical comparison of three immunoassay platforms for subpicomolar detection of protein biomarker GAD65

Olivier R. Costa; Katrijn Verhaeghen; Sarah Roels; Geert Stangé; Zhidong Ling; Daniel Pipeleers; Frans K. Gorus; Geert A. Martens

doi:10.1371/journal.pone.0193670

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Open Access

Peer-reviewed

Research Article

An analytical comparison of three immunoassay platforms for subpicomolar detection of protein biomarker GAD65

Olivier R. Costa ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft

* E-mail: olivier.costa@uzbrussel.be

Affiliations Department of Clinical Biology, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium, Center for Beta Cell Therapy in Diabetes, Brussels Free University (VUB), Brussels, Belgium

http://orcid.org/0000-0002-0190-5819

⨯
Katrijn Verhaeghen,

Roles Investigation, Methodology, Validation, Writing – review & editing

Affiliation Department of Clinical Biology, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium
⨯
Sarah Roels,

Roles Data curation, Validation, Writing – review & editing

Affiliation Center for Beta Cell Therapy in Diabetes, Brussels Free University (VUB), Brussels, Belgium
⨯
Geert Stangé,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Center for Beta Cell Therapy in Diabetes, Brussels Free University (VUB), Brussels, Belgium
⨯
Zhidong Ling,

Roles Resources, Validation

Affiliation Center for Beta Cell Therapy in Diabetes, Brussels Free University (VUB), Brussels, Belgium
⨯
Daniel Pipeleers,

Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Center for Beta Cell Therapy in Diabetes, Brussels Free University (VUB), Brussels, Belgium
⨯
Frans K. Gorus,

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – review & editing

Affiliations Department of Clinical Biology, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium, Center for Beta Cell Therapy in Diabetes, Brussels Free University (VUB), Brussels, Belgium
⨯
Geert A. Martens

Roles Data curation, Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliations Center for Beta Cell Therapy in Diabetes, Brussels Free University (VUB), Brussels, Belgium, Department of Laboratory Medicine, AZ Delta, Roeselare, Belgium
⨯

An analytical comparison of three immunoassay platforms for subpicomolar detection of protein biomarker GAD65

Olivier R. Costa,
Katrijn Verhaeghen,
Sarah Roels,
Geert Stangé,
Zhidong Ling,
Daniel Pipeleers,
Frans K. Gorus,
Geert A. Martens

Published: March 8, 2018
https://doi.org/10.1371/journal.pone.0193670

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Immunoassays
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Enzyme-linked immunoassays
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Blood plasma
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Biomarkers
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Diabetes mellitus
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Electrochemistry
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Monoclonal antibodies
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Signal amplification
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