A new high-performance liquid chromatography-tandem mass spectrometry method for the determination of paclitaxel and 6α-hydroxy-paclitaxel in human plasma: Development, validation and application in a clinical pharmacokinetic study

• Bianca Posocco,

  Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliation Experimental and Clinical Pharmacology, CRO- National Cancer Institute, Aviano, Pordenone, Italy

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• Mauro Buzzo,

  Roles Data curation, Formal analysis

  Affiliation Experimental and Clinical Pharmacology, CRO- National Cancer Institute, Aviano, Pordenone, Italy

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• Andrea Follegot,

  Roles Data curation, Formal analysis

  Affiliation Experimental and Clinical Pharmacology, CRO- National Cancer Institute, Aviano, Pordenone, Italy

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• Luciana Giodini,

  Roles Data curation, Formal analysis

  Affiliation Experimental and Clinical Pharmacology, CRO- National Cancer Institute, Aviano, Pordenone, Italy

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• Roberto Sorio,

  Roles Conceptualization

  Affiliation Oncology Unit B, CRO- National Cancer Institute, Aviano, Pordenone, Italy

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• Elena Marangon ,

  Contributed equally to this work with: Elena Marangon, Giuseppe Toffoli

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Writing – review & editing

  * E-mail: emarangon@cro.it

  Affiliation Experimental and Clinical Pharmacology, CRO- National Cancer Institute, Aviano, Pordenone, Italy

  http://orcid.org/0000-0001-6333-2369

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• Giuseppe Toffoli

  Contributed equally to this work with: Elena Marangon, Giuseppe Toffoli

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Experimental and Clinical Pharmacology, CRO- National Cancer Institute, Aviano, Pordenone, Italy

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