Genomic and transcriptomic comparison of allergen and silver nanoparticle-induced mast cell degranulation reveals novel non-immunoglobulin E mediated mechanisms

Monica Johnson; Nasser Alsaleh; Ryan P. Mendoza; Indushekhar Persaud; Alison K. Bauer; Laura Saba; Jared M. Brown

doi:10.1371/journal.pone.0193499

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Open Access

Peer-reviewed

Research Article

Genomic and transcriptomic comparison of allergen and silver nanoparticle-induced mast cell degranulation reveals novel non-immunoglobulin E mediated mechanisms

Monica Johnson,

Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, United States of America
⨯
Nasser Alsaleh,

Roles Investigation

Affiliation Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, United States of America
⨯
Ryan P. Mendoza,

Roles Investigation

Affiliation Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, United States of America
⨯
Indushekhar Persaud,

Roles Investigation

Affiliation Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, United States of America
⨯
Alison K. Bauer,

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliation Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado, Aurora, CO, United States of America
⨯
Laura Saba,

Roles Conceptualization, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, United States of America
⨯
Jared M. Brown

Roles Conceptualization, Funding acquisition, Project administration, Resources, Writing – original draft, Writing – review & editing

* E-mail: jared.brown@ucdenver.edu

Affiliation Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, United States of America

http://orcid.org/0000-0003-3909-5388

⨯

Genomic and transcriptomic comparison of allergen and silver nanoparticle-induced mast cell degranulation reveals novel non-immunoglobulin E mediated mechanisms

Monica Johnson,
Nasser Alsaleh,
Ryan P. Mendoza,
Indushekhar Persaud,
Alison K. Bauer,
Laura Saba,
Jared M. Brown

Published: March 22, 2018
https://doi.org/10.1371/journal.pone.0193499

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Cell degranulation
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Genetic loci
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