Bidesmosidic betulin saponin bearing L-rhamnopyranoside moieties induces apoptosis and inhibition of lung cancer cells growth in vitro and in vivo

Mouadh Mihoub; André Pichette; Balla Sylla; Charles Gauthier; Jean Legault

doi:10.1371/journal.pone.0193386

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Open Access

Peer-reviewed

Research Article

Bidesmosidic betulin saponin bearing L-rhamnopyranoside moieties induces apoptosis and inhibition of lung cancer cells growth in vitro and in vivo

Mouadh Mihoub,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Chaire de Recherche sur les Agents Anticancéreux d’Origine Naturelle, Laboratoire LASEVE, Université du Québec à Chicoutimi, Département des Sciences Fondamentales, 555 boul. de l’Université, Chicoutimi (Québec), Canada
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André Pichette,

Roles Funding acquisition, Project administration, Resources, Validation, Writing – review & editing

Affiliation Chaire de Recherche sur les Agents Anticancéreux d’Origine Naturelle, Laboratoire LASEVE, Université du Québec à Chicoutimi, Département des Sciences Fondamentales, 555 boul. de l’Université, Chicoutimi (Québec), Canada
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Balla Sylla,

Roles Investigation, Writing – review & editing

Affiliation Chaire de Recherche sur les Agents Anticancéreux d’Origine Naturelle, Laboratoire LASEVE, Université du Québec à Chicoutimi, Département des Sciences Fondamentales, 555 boul. de l’Université, Chicoutimi (Québec), Canada
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Charles Gauthier,

Roles Investigation, Writing – review & editing

Affiliations Chaire de Recherche sur les Agents Anticancéreux d’Origine Naturelle, Laboratoire LASEVE, Université du Québec à Chicoutimi, Département des Sciences Fondamentales, 555 boul. de l’Université, Chicoutimi (Québec), Canada, INRS-Institut Armand-Frappier, Université du Québec, 531 boul. des Prairies, Laval (Québec), Canada
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Jean Legault

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: Jean.Legault@uqac.ca

Affiliation Chaire de Recherche sur les Agents Anticancéreux d’Origine Naturelle, Laboratoire LASEVE, Université du Québec à Chicoutimi, Département des Sciences Fondamentales, 555 boul. de l’Université, Chicoutimi (Québec), Canada

http://orcid.org/0000-0001-6292-6798

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Bidesmosidic betulin saponin bearing L-rhamnopyranoside moieties induces apoptosis and inhibition of lung cancer cells growth in vitro and in vivo

Mouadh Mihoub,
André Pichette,
Balla Sylla,
Charles Gauthier,
Jean Legault

Published: March 14, 2018
https://doi.org/10.1371/journal.pone.0193386

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Apoptosis
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Non-small cell lung cancer
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Lung and intrathoracic tumors
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Mitochondria
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Cancer treatment
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Cytotoxicity
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Malonates
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DNA fragmentation
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