Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion

Krister Bamberg; Ulrika Johansson; Karl Edman; Lena William-Olsson; Susanna Myhre; Anders Gunnarsson; Stefan Geschwindner; Anna Aagaard; Anna Björnson Granqvist; Frédéric Jaisser; Yufeng Huang; Kenneth L. Granberg; Rasmus Jansson-Löfmark; Judith Hartleib-Geschwindner

doi:10.1371/journal.pone.0193380

Loading metrics

Open Access

Peer-reviewed

Research Article

Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion

Krister Bamberg ,

Roles Conceptualization, Formal analysis, Methodology, Writing – original draft

* E-mail: krister.bamberg@astrazeneca.com

Affiliation Cardiovascular, Renal and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden

http://orcid.org/0000-0002-0538-6083

⨯
Ulrika Johansson,

Roles Conceptualization, Methodology, Writing – original draft

Affiliation Cardiovascular, Renal and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Karl Edman,

Roles Conceptualization, Formal analysis, Writing – original draft

Affiliation Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Lena William-Olsson,

Roles Conceptualization, Methodology, Writing – original draft

Affiliation Cardiovascular, Renal and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Susanna Myhre,

Roles Methodology

Affiliation Cardiovascular, Renal and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Anders Gunnarsson,

Roles Methodology, Writing – original draft

Affiliation Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Stefan Geschwindner,

Roles Methodology, Writing – original draft

Affiliation Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Anna Aagaard,

Roles Methodology

Affiliation Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Anna Björnson Granqvist,

Roles Writing – review & editing

Affiliation Cardiovascular, Renal and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Frédéric Jaisser,

Roles Conceptualization, Writing – review & editing

Affiliation Centre de Recherche des Cordeliers, INSERM U1138 Team 1, Paris, France
⨯
Yufeng Huang,

Roles Methodology, Writing – review & editing

Affiliation Division of Nephrology & Hypertension, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
⨯
Kenneth L. Granberg,

Roles Conceptualization, Writing – review & editing

Affiliation Cardiovascular, Renal and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Rasmus Jansson-Löfmark,

Roles Conceptualization, Formal analysis, Writing – original draft

Affiliation Cardiovascular, Renal and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Judith Hartleib-Geschwindner

Roles Conceptualization, Writing – original draft

Affiliation Cardiovascular, Renal and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯

Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion

Krister Bamberg,
Ulrika Johansson,
Karl Edman,
Lena William-Olsson,
Susanna Myhre,
Anders Gunnarsson,
Stefan Geschwindner,
Anna Aagaard,
Anna Björnson Granqvist,
Frédéric Jaisser

Published: February 23, 2018
https://doi.org/10.1371/journal.pone.0193380

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

ACE inhibitor therapy
Is the Subject Area "ACE inhibitor therapy" applicable to this article?

Thanks for your feedback.
Aldosterone
Is the Subject Area "Aldosterone" applicable to this article?

Thanks for your feedback.
Electrolytes
Is the Subject Area "Electrolytes" applicable to this article?

Thanks for your feedback.
Excretion
Is the Subject Area "Excretion" applicable to this article?

Thanks for your feedback.
Urine
Is the Subject Area "Urine" applicable to this article?

Thanks for your feedback.
Kidneys
Is the Subject Area "Kidneys" applicable to this article?

Thanks for your feedback.
Diabetes mellitus
Is the Subject Area "Diabetes mellitus" applicable to this article?

Thanks for your feedback.
Blood plasma
Is the Subject Area "Blood plasma" applicable to this article?

Thanks for your feedback.