Docosahexaenoic acid antagonizes the boosting effect of palmitic acid on LPS inflammatory signaling by inhibiting gene transcription and ceramide synthesis

Junfei Jin; Zhongyang Lu; Yanchun Li; L. Ashley Cowart; Maria F. Lopes-Virella; Yan Huang

doi:10.1371/journal.pone.0193343

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Peer-reviewed

Research Article

Docosahexaenoic acid antagonizes the boosting effect of palmitic acid on LPS inflammatory signaling by inhibiting gene transcription and ceramide synthesis

Junfei Jin,

Roles Formal analysis, Investigation

Current address: Laboratory of Liver-Biliary Tract-Pancreas Surgery, Affiliated Hospital of Guilin Medical University, Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, Guilin, Guangxi, People's Republic of China

Affiliation Division of Endocrinology, Diabetes and Medical Genetics, Department of Medicine, Medical University of South Carolina, Charleston, United States of America
⨯
Zhongyang Lu,

Roles Formal analysis, Investigation

Affiliation Ralph H. Johnson Veterans Affairs Medical Center, Charleston, United States of America
⨯
Yanchun Li,

Roles Formal analysis, Investigation

Affiliation Division of Endocrinology, Diabetes and Medical Genetics, Department of Medicine, Medical University of South Carolina, Charleston, United States of America
⨯
L. Ashley Cowart,

Roles Formal analysis, Investigation

Current address: Department of Biochemistry, College of Medicine, Virginia Commonwealth University, Richmond, Virginia United States of America

Affiliation Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, United States of America
⨯
Maria F. Lopes-Virella,

Roles Formal analysis, Writing – review & editing

Affiliations Division of Endocrinology, Diabetes and Medical Genetics, Department of Medicine, Medical University of South Carolina, Charleston, United States of America, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, United States of America
⨯
Yan Huang

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft

* E-mail: huangyan@musc.edu

Affiliations Division of Endocrinology, Diabetes and Medical Genetics, Department of Medicine, Medical University of South Carolina, Charleston, United States of America, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, United States of America

http://orcid.org/0000-0003-2789-5580

⨯

Docosahexaenoic acid antagonizes the boosting effect of palmitic acid on LPS inflammatory signaling by inhibiting gene transcription and ceramide synthesis

Junfei Jin,
Zhongyang Lu,
Yanchun Li,
L. Ashley Cowart,
Maria F. Lopes-Virella,
Yan Huang

Published: February 23, 2018
https://doi.org/10.1371/journal.pone.0193343

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