Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen

Priya Revathikumar; Johanna Estelius; Utsa Karmakar; Erwan Le Maître; Marina Korotkova; Per-Johan Jakobsson; Jon Lampa

doi:10.1371/journal.pone.0193210

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Peer-reviewed

Research Article

Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen

Priya Revathikumar,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
⨯
Johanna Estelius,

Roles Investigation, Methodology, Supervision, Visualization, Writing – review & editing

Affiliation Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

http://orcid.org/0000-0003-0275-2559

⨯
Utsa Karmakar,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
⨯
Erwan Le Maître,

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
⨯
Marina Korotkova,

Roles Supervision, Writing – review & editing

Affiliation Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
⨯
Per-Johan Jakobsson,

Roles Supervision, Writing – review & editing

Affiliation Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
⨯
Jon Lampa

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: jon.lampa@ki.se

Affiliation Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
⨯

Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen

Priya Revathikumar,
Johanna Estelius,
Utsa Karmakar,
Erwan Le Maître,
Marina Korotkova,
Per-Johan Jakobsson,
Jon Lampa

Published: February 22, 2018
https://doi.org/10.1371/journal.pone.0193210

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