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Open Access

Peer-reviewed

Research Article

Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein

Lucie Aumailley,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Centre de recherche du CHU de Québec, Faculty of Medicine, Université Laval, Quebec City Québec, Canada
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Florence Roux-Dalvai,

Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Proteomics Platform Center, Centre de recherche du CHU de Québec, Faculty of Medicine, Université Laval, Quebec City Québec, Canada
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Isabelle Kelly,

Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Proteomics Platform Center, Centre de recherche du CHU de Québec, Faculty of Medicine, Université Laval, Quebec City Québec, Canada
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Arnaud Droit,

Roles Resources, Software, Supervision, Writing – review & editing

Affiliation Proteomics Platform Center, Centre de recherche du CHU de Québec, Faculty of Medicine, Université Laval, Quebec City Québec, Canada
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Michel Lebel

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Visualization, Writing – original draft

* E-mail: michel.lebel@crchudequebec.ulaval.ca

Affiliation Centre de recherche du CHU de Québec, Faculty of Medicine, Université Laval, Quebec City Québec, Canada

http://orcid.org/0000-0002-3499-7174

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Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein

Lucie Aumailley,
Florence Roux-Dalvai,
Isabelle Kelly,
Arnaud Droit,
Michel Lebel

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Published: March 1, 2018
https://doi.org/10.1371/journal.pone.0193170

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Vitamin C
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Mouse models
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Endoplasmic reticulum
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Immunoblotting
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Messenger RNA
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Protein expression
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Chaperone proteins
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Principal component analysis
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