Treatment of infected lungs by ex vivo perfusion with high dose antibiotics and autotransplantation: A pilot study in pigs

• Norman Zinne ,

  Contributed equally to this work with: Norman Zinne, Marcus Krueger

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: zinne.norman@mh-hannover.de

  Affiliation Department of Cardiothoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Lower Saxony, Germany

  http://orcid.org/0000-0003-3277-8645

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• Marcus Krueger ,

  Contributed equally to this work with: Norman Zinne, Marcus Krueger

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Cardiothoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Lower Saxony, Germany

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• Doris Hoeltig,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Writing – original draft, Writing – review & editing

  Affiliation Clinic for Swine, Small Ruminants, Forensic Medicine, and Ambulatory Service, University of Veterinary Medicine Hannover, Hannover, Lower Saxony, Germany

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• Burkhard Tuemmler,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliations Clinic for Paediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Lower Saxony, Germany, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Lower Saxony, Germany

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• Erin C. Boyle,

  Roles Formal analysis, Writing – original draft, Writing – review & editing

  Affiliation Department of Cardiothoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Lower Saxony, Germany

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• Christian Biancosino,

  Roles Investigation

  Affiliation Department of Cardiothoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Lower Saxony, Germany

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• Klaus Hoeffler,

  Roles Investigation, Methodology, Resources

  Affiliation Department of Cardiothoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Lower Saxony, Germany

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• Peter Braubach,

  Roles Formal analysis

  Affiliations Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Lower Saxony, Germany, Institute for Pathology, Hannover Medical School, Hannover, Lower Saxony, Germany

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• Taufiek K. Rajab,

  Roles Writing – original draft

  Affiliation Department of Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Anatol Ciubotaru,

  Roles Investigation

  Affiliation Department of Cardiothoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Lower Saxony, Germany

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• Judith Rohde,

  Roles Conceptualization, Data curation, Investigation, Resources

  Affiliation Department of Infectious Diseases, Institute for Microbiology, University of Veterinary Medicine Hannover, Hannover, Lower Saxony, Germany

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• Karl-Heinz Waldmann,

  Roles Conceptualization, Data curation, Methodology, Project administration, Resources, Supervision, Writing – original draft

  Affiliation Clinic for Swine, Small Ruminants, Forensic Medicine, and Ambulatory Service, University of Veterinary Medicine Hannover, Hannover, Lower Saxony, Germany

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• Axel Haverich

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft

  Affiliations Department of Cardiothoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Lower Saxony, Germany, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Lower Saxony, Germany

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