Metformin suppresses retinal angiogenesis and inflammation in vitro and in vivo

Jing Han; Yue Li; Xiuli Liu; Tongrong Zhou; Haijing Sun; Paul Edwards; Hua Gao; Fu-Shin Yu; Xiaoxi Qiao

doi:10.1371/journal.pone.0193031

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Open Access

Peer-reviewed

Research Article

Metformin suppresses retinal angiogenesis and inflammation in vitro and in vivo

Jing Han,

Roles Data curation, Formal analysis, Investigation, Writing – original draft

Affiliations Department of Ophthalmology, Henry Ford Health System, Detroit, Michigan, United States of America, Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi, People’s Republic of China
⨯
Yue Li,

Roles Formal analysis, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Ophthalmology, Henry Ford Health System, Detroit, Michigan, United States of America
⨯
Xiuli Liu,

Roles Investigation, Methodology

Affiliation Department of Ophthalmology, Henry Ford Health System, Detroit, Michigan, United States of America
⨯
Tongrong Zhou,

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Ophthalmology, Henry Ford Health System, Detroit, Michigan, United States of America
⨯
Haijing Sun,

Roles Investigation, Methodology

Affiliation Departments of Ophthalmology and Anatomy and Cell Biology, Wayne State University, School of Medicine, Detroit, Michigan, United States of America
⨯
Paul Edwards,

Roles Funding acquisition

Affiliation Department of Ophthalmology, Henry Ford Health System, Detroit, Michigan, United States of America
⨯
Hua Gao,

Roles Validation

Affiliation Department of Ophthalmology, Henry Ford Health System, Detroit, Michigan, United States of America
⨯
Fu-Shin Yu,

Roles Supervision

Affiliation Departments of Ophthalmology and Anatomy and Cell Biology, Wayne State University, School of Medicine, Detroit, Michigan, United States of America
⨯
Xiaoxi Qiao

Roles Conceptualization, Investigation, Project administration, Supervision, Validation, Writing – review & editing

* E-mail: xqiao1@hfhs.org

Affiliation Department of Ophthalmology, Henry Ford Health System, Detroit, Michigan, United States of America

http://orcid.org/0000-0002-4376-9472

⨯

Metformin suppresses retinal angiogenesis and inflammation in vitro and in vivo

Jing Han,
Yue Li,
Xiuli Liu,
Tongrong Zhou,
Haijing Sun,
Paul Edwards,
Hua Gao,
Fu-Shin Yu,
Xiaoxi Qiao

Published: March 7, 2018
https://doi.org/10.1371/journal.pone.0193031

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Diabetes mellitus
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Retina
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