Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner

• Chisato Sumi,

  Roles Conceptualization, Data curation, Investigation, Writing – original draft, Writing – review & editing

  Affiliations Department of Anesthesiology, Kansai Medical University, Hirakata, Japan, Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University, Hirakata, Japan

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• Akihisa Okamoto,

  Roles Conceptualization, Funding acquisition, Investigation, Writing – review & editing

  Affiliation Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University, Hirakata, Japan

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• Hiromasa Tanaka,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University, Hirakata, Japan

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• Kenichiro Nishi,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University, Hirakata, Japan

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• Munenori Kusunoki,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Anesthesiology, Kansai Medical University, Hirakata, Japan, Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University, Hirakata, Japan

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• Tomohiro Shoji,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Anesthesiology, Kansai Medical University, Hirakata, Japan, Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University, Hirakata, Japan

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• Takeo Uba,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Anesthesiology, Kansai Medical University, Hirakata, Japan, Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University, Hirakata, Japan

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• Yoshiyuki Matsuo,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University, Hirakata, Japan

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• Takehiko Adachi,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Anesthesiology, Tazuke Kofukai Medical Institute Kitano Hospital, Osaka, Japan

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• Jun-Ichi Hayashi,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation University of Tsukuba, Tsukuba, Japan

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• Keizo Takenaga,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation Department of Life Science, Shimane University Faculty of Medicine, Izumo, Japan

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• Kiichi Hirota

  Roles Conceptualization, Data curation, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: hif1@mac.com

  Affiliation Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University, Hirakata, Japan

  http://orcid.org/0000-0003-1110-0827

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