Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression

• Yanxia Guo ,

  Contributed equally to this work with: Yanxia Guo, Alice M. Walsh, Mary Canavan

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Immunology, Janssen Research, Pennsylvania, United States of America

  ⨯
• Alice M. Walsh ,

  Contributed equally to this work with: Yanxia Guo, Alice M. Walsh, Mary Canavan

  Roles Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Immunology, Janssen Research, Pennsylvania, United States of America

  ⨯
• Mary Canavan ,

  Contributed equally to this work with: Yanxia Guo, Alice M. Walsh, Mary Canavan

  Roles Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – review & editing

  Affiliation Molecular Rheumatology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland

  ⨯
• Mihir D. Wechalekar,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Rheumatology Unit, Repatriation General Hospital and Flinders University, Adelaide, Australia

  ⨯
• Suzanne Cole,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Immunology, Janssen Research, Pennsylvania, United States of America

  ⨯
• Xuefeng Yin,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Immunology, Janssen Research, Pennsylvania, United States of America

  ⨯
• Brittney Scott,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Immunology, Janssen Research, Pennsylvania, United States of America

  ⨯
• Mathew Loza,

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Immunology, Janssen Research, Pennsylvania, United States of America

  ⨯
• Carl Orr,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Centre for Arthritis and Rheumatic Diseases, St. Vincent's University Hospital, University College Dublin, Elm Park, Dublin, Ireland

  ⨯
• Trudy McGarry,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Molecular Rheumatology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland

  ⨯
• Michele Bombardieri,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Queen Mary University of London, Charterhouse Square, London, United Kingdom

  ⨯
• Frances Humby,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Queen Mary University of London, Charterhouse Square, London, United Kingdom

  ⨯
• Susanna M. Proudman,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia and Discipline of Medicine, University of Adelaide, Adelaide, Australia

  ⨯
• Costantino Pitzalis,

  Roles Data curation, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Queen Mary University of London, Charterhouse Square, London, United Kingdom

  ⨯
• Malcolm D. Smith,

  Roles Data curation, Formal analysis, Investigation, Supervision, Writing – review & editing

  Affiliation Rheumatology Unit, Repatriation General Hospital and Flinders University, Adelaide, Australia

  ⨯
• Joshua R. Friedman,

  Roles Investigation, Project administration, Supervision, Writing – review & editing

  Affiliation Immunology, Janssen Research, Pennsylvania, United States of America

  ⨯
• Ian Anderson,

  Roles Formal analysis, Funding acquisition, Writing – review & editing

  Affiliation Immunology, Janssen Research, Pennsylvania, United States of America

  ⨯
• Loui Madakamutil,

  Roles Formal analysis, Funding acquisition, Writing – review & editing

  Affiliation Immunology, Janssen Research, Pennsylvania, United States of America

  ⨯
• Douglas J. Veale,

  Roles Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Centre for Arthritis and Rheumatic Diseases, St. Vincent's University Hospital, University College Dublin, Elm Park, Dublin, Ireland

  ⨯
• Ursula Fearon ,

  Roles Formal analysis, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: snagpal2@its.jnj.com(SN); ursula.fearon@ucd.ie (UF)

  Affiliation Molecular Rheumatology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland

  ⨯
•  [ ... ],
• Sunil Nagpal

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: snagpal2@its.jnj.com(SN); ursula.fearon@ucd.ie (UF)

  Affiliation Immunology, Janssen Research, Pennsylvania, United States of America

  http://orcid.org/0000-0001-6090-8780

  ⨯
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