Ligand binding modulates the structural dynamics and activity of urokinase-type plasminogen activator: A possible mechanism of plasminogen activation

• Tobias Kromann-Hansen ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – original draft

  * E-mail: tkromanntofting@ucsd.edu

  Current address: Department of Immunology and Biochemistry, Lillebaelt Hospital, Beriderbakken 4, Vejle, Denmark.

  Affiliations Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California, United States, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

  http://orcid.org/0000-0003-0667-9096

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• Eva Louise Lange,

  Roles Investigation

  Affiliation Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

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• Ida K. Lund,

  Roles Writing – review & editing

  Affiliations The Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark, Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark

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• Gunilla Høyer-Hansen,

  Roles Writing – review & editing

  Affiliations The Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark, Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark

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• Peter A. Andreasen,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

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• Elizabeth A. Komives

  Roles Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California, United States

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