Role of α7nAChR-NMDAR in sevoflurane-induced memory deficits in the developing rat hippocampus

XiaoHong Tang; YiZe Li; JiYing Ao; Ling Ding; Yang Liu; Yuan Yuan; ZhiFen Wang; GuoLin Wang

doi:10.1371/journal.pone.0192498

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Open Access

Peer-reviewed

Research Article

Role of α7nAChR-NMDAR in sevoflurane-induced memory deficits in the developing rat hippocampus

XiaoHong Tang,

Roles Data curation, Writing – original draft

Affiliations Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, P. R. China, Tianjin Research Institute of Anesthesiology, Tianjin, P. R. China
⨯
YiZe Li,

Roles Conceptualization, Methodology

Affiliations Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, P. R. China, Tianjin Research Institute of Anesthesiology, Tianjin, P. R. China
⨯
JiYing Ao,

Roles Resources, Software

Affiliations Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, P. R. China, Tianjin Research Institute of Anesthesiology, Tianjin, P. R. China
⨯
Ling Ding,

Roles Resources, Supervision

Affiliations Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, P. R. China, Tianjin Research Institute of Anesthesiology, Tianjin, P. R. China
⨯
Yang Liu,

Roles Resources, Software

Affiliation School of Biomedical Engineering, Tianjin Medical University, Tianjin, P. R. China
⨯
Yuan Yuan,

Roles Formal analysis, Methodology

Affiliations Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, P. R. China, Tianjin Research Institute of Anesthesiology, Tianjin, P. R. China
⨯
ZhiFen Wang,

Roles Resources, Supervision

Affiliations Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, P. R. China, Tianjin Research Institute of Anesthesiology, Tianjin, P. R. China
⨯
GuoLin Wang

Roles Validation, Writing – review & editing

* E-mail: wangguolinemail@126.com

Affiliations Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, P. R. China, Tianjin Research Institute of Anesthesiology, Tianjin, P. R. China

http://orcid.org/0000-0002-9369-1984

⨯

Role of α7nAChR-NMDAR in sevoflurane-induced memory deficits in the developing rat hippocampus

XiaoHong Tang,
YiZe Li,
JiYing Ao,
Ling Ding,
Yang Liu,
Yuan Yuan,
ZhiFen Wang,
GuoLin Wang

Published: February 5, 2018
https://doi.org/10.1371/journal.pone.0192498

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Neuronal dendrites
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Hippocampus
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Intracellular membranes
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Membrane trafficking
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Nicotinic acetylcholine receptors
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Working memory
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