Clonal chromosomal and genomic instability during human multipotent mesenchymal stromal cells long-term culture

Victoria Nikitina; Tatiana Astrelina; Vladimir Nugis; Aleksandr Ostashkin; Tatiana Karaseva; Ekaterina Dobrovolskaya; Dariya Usupzhanova; Yulia Suchkova; Elena Lomonosova; Sergey Rodin; Vitaliy Brunchukov; Stanislav Lauk-Dubitskiy; Valentin Brumberg; Anastasia Machova; Irina Kobzeva; Andrey Bushmanov; Aleksandr Samoilov

doi:10.1371/journal.pone.0192445

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Open Access

Peer-reviewed

Research Article

Clonal chromosomal and genomic instability during human multipotent mesenchymal stromal cells long-term culture

Victoria Nikitina ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: nikitinava@yandex.ru

Affiliation State Research Center, Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency of Russia, Moscow, Russia

http://orcid.org/0000-0002-3150-7686

⨯
Tatiana Astrelina,

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation State Research Center, Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency of Russia, Moscow, Russia
⨯
Vladimir Nugis,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

Affiliation State Research Center, Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency of Russia, Moscow, Russia
⨯
Aleksandr Ostashkin,

Roles Investigation

Affiliation State Research Center, Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency of Russia, Moscow, Russia
⨯
Tatiana Karaseva,

Roles Investigation, Validation

Affiliation State Research Center, Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency of Russia, Moscow, Russia
⨯
Ekaterina Dobrovolskaya,

Roles Investigation

Affiliation State Research Center, Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency of Russia, Moscow, Russia
⨯
Dariya Usupzhanova,

Roles Investigation

Affiliation State Research Center, Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency of Russia, Moscow, Russia
⨯
Yulia Suchkova,

Roles Investigation

Affiliation State Research Center, Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency of Russia, Moscow, Russia
⨯
Elena Lomonosova,

Roles Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation State Research Center, Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency of Russia, Moscow, Russia
⨯
Sergey Rodin,

Roles Writing – original draft, Writing – review & editing

Affiliation Department of Medical Biochemistry and Biophysics Karolinska Institutet, Stockholm, Sweden
⨯
Vitaliy Brunchukov,

Roles Investigation

Affiliation State Research Center, Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency of Russia, Moscow, Russia
⨯
Stanislav Lauk-Dubitskiy,

Roles Investigation

Affiliation State Research Center, Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency of Russia, Moscow, Russia
⨯
Valentin Brumberg,

Roles Investigation

Affiliation State Research Center, Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency of Russia, Moscow, Russia
⨯
Anastasia Machova,

Roles Investigation

Affiliation State Research Center, Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency of Russia, Moscow, Russia
⨯
Irina Kobzeva,

Roles Investigation

Affiliation State Research Center, Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency of Russia, Moscow, Russia
⨯
Andrey Bushmanov,

Roles Funding acquisition, Resources, Supervision

Affiliation State Research Center, Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency of Russia, Moscow, Russia
⨯
[ ... ],
Aleksandr Samoilov

Roles Funding acquisition, Resources, Supervision, Validation

Affiliation State Research Center, Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency of Russia, Moscow, Russia
⨯
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Clonal chromosomal and genomic instability during human multipotent mesenchymal stromal cells long-term culture

Victoria Nikitina,
Tatiana Astrelina,
Vladimir Nugis,
Aleksandr Ostashkin,
Tatiana Karaseva,
Ekaterina Dobrovolskaya,
Dariya Usupzhanova,
Yulia Suchkova,
Elena Lomonosova,
Sergey Rodin

Published: February 12, 2018
https://doi.org/10.1371/journal.pone.0192445

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Cloning
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Chromosomal translocations
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Karyotypes
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Mesenchymal stem cells
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Polyploidy
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Chromosomal aberrations
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