CCR2 antagonism leads to marked reduction in proteinuria and glomerular injury in murine models of focal segmental glomerulosclerosis (FSGS)

Zhenhua Miao; Linda S. Ertl; Dale Newland; Bin Zhao; Yu Wang; Xiaoping Zang; James J. Campbell; Xiaoli Liu; Ton Dang; Shichang Miao; Antoni Krasinski; Sreenivas Punna; Yibin Zeng; Jeffrey McMahon; Penglie Zhang; Israel F. Charo; Thomas J. Schall; Rajinder Singh

doi:10.1371/journal.pone.0192405

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Open Access

Peer-reviewed

Research Article

CCR2 antagonism leads to marked reduction in proteinuria and glomerular injury in murine models of focal segmental glomerulosclerosis (FSGS)

Zhenhua Miao,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation ChemoCentryx, Inc., Mountain View, CA, United States of America
⨯
Linda S. Ertl,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Visualization

Affiliation ChemoCentryx, Inc., Mountain View, CA, United States of America
⨯
Dale Newland,

Roles Investigation, Methodology, Visualization

Affiliation ChemoCentryx, Inc., Mountain View, CA, United States of America
⨯
Bin Zhao,

Roles Data curation, Formal analysis, Methodology, Validation

Affiliation ChemoCentryx, Inc., Mountain View, CA, United States of America
⨯
Yu Wang,

Roles Data curation, Methodology, Supervision, Visualization

Affiliation ChemoCentryx, Inc., Mountain View, CA, United States of America
⨯
Xiaoping Zang,

Roles Data curation, Formal analysis, Methodology, Visualization

Affiliation ChemoCentryx, Inc., Mountain View, CA, United States of America
⨯
James J. Campbell,

Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation ChemoCentryx, Inc., Mountain View, CA, United States of America
⨯
Xiaoli Liu,

Roles Data curation, Formal analysis, Investigation, Visualization

Affiliation ChemoCentryx, Inc., Mountain View, CA, United States of America
⨯
Ton Dang,

Roles Data curation, Formal analysis, Methodology

Affiliation ChemoCentryx, Inc., Mountain View, CA, United States of America
⨯
Shichang Miao,

Roles Data curation, Investigation, Resources, Supervision, Visualization

Affiliation ChemoCentryx, Inc., Mountain View, CA, United States of America
⨯
Antoni Krasinski,

Roles Investigation

Affiliation ChemoCentryx, Inc., Mountain View, CA, United States of America
⨯
Sreenivas Punna,

Roles Investigation

Affiliation ChemoCentryx, Inc., Mountain View, CA, United States of America
⨯
Yibin Zeng,

Roles Investigation

Affiliation ChemoCentryx, Inc., Mountain View, CA, United States of America
⨯
Jeffrey McMahon,

Roles Investigation, Methodology, Resources, Validation

Affiliation ChemoCentryx, Inc., Mountain View, CA, United States of America
⨯
Penglie Zhang,

Roles Conceptualization, Formal analysis, Project administration, Supervision, Visualization

Affiliation ChemoCentryx, Inc., Mountain View, CA, United States of America
⨯
Israel F. Charo,

Roles Formal analysis, Visualization, Writing – original draft, Writing – review & editing

Affiliation ChemoCentryx, Inc., Mountain View, CA, United States of America
⨯
Thomas J. Schall,

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Visualization, Writing – review & editing

Affiliation ChemoCentryx, Inc., Mountain View, CA, United States of America
⨯
[ ... ],
Rajinder Singh

Roles Conceptualization, Investigation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: rsingh@chemocentryx.com

Affiliation ChemoCentryx, Inc., Mountain View, CA, United States of America

http://orcid.org/0000-0001-5981-535X

⨯
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CCR2 antagonism leads to marked reduction in proteinuria and glomerular injury in murine models of focal segmental glomerulosclerosis (FSGS)

Zhenhua Miao,
Linda S. Ertl,
Dale Newland,
Bin Zhao,
Yu Wang,
Xiaoping Zang,
James J. Campbell,
Xiaoli Liu,
Ton Dang,
Shichang Miao

Published: March 21, 2018
https://doi.org/10.1371/journal.pone.0192405

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