Chronic morphine exposure potentiates p-glycoprotein trafficking from nuclear reservoirs in cortical rat brain microvessels

Charles P. Schaefer; Nathan B. Arkwright; Leigh M. Jacobs; Chelsea K. Jarvis; Kristen C. Hunn; Tally M. Largent-Milnes; Margaret E. Tome; Thomas P. Davis

doi:10.1371/journal.pone.0192340

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Open Access

Peer-reviewed

Research Article

Chronic morphine exposure potentiates p-glycoprotein trafficking from nuclear reservoirs in cortical rat brain microvessels

Charles P. Schaefer,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Department of Pharmacology, University of Arizona, Tucson, Arizona, United States of America
⨯
Nathan B. Arkwright,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Pharmacology, University of Arizona, Tucson, Arizona, United States of America
⨯
Leigh M. Jacobs,

Roles Investigation

Affiliation Department of Pharmacology, University of Arizona, Tucson, Arizona, United States of America
⨯
Chelsea K. Jarvis,

Roles Investigation

Affiliation Department of Pharmacology, University of Arizona, Tucson, Arizona, United States of America
⨯
Kristen C. Hunn,

Roles Investigation

Affiliation Department of Pharmacology, University of Arizona, Tucson, Arizona, United States of America
⨯
Tally M. Largent-Milnes,

Roles Conceptualization, Methodology

Affiliation Department of Pharmacology, University of Arizona, Tucson, Arizona, United States of America
⨯
Margaret E. Tome ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: mtome@email.arizona.edu

Affiliation Department of Pharmacology, University of Arizona, Tucson, Arizona, United States of America

http://orcid.org/0000-0002-1104-9665

⨯
Thomas P. Davis

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliation Department of Pharmacology, University of Arizona, Tucson, Arizona, United States of America
⨯

Chronic morphine exposure potentiates p-glycoprotein trafficking from nuclear reservoirs in cortical rat brain microvessels

Charles P. Schaefer,
Nathan B. Arkwright,
Leigh M. Jacobs,
Chelsea K. Jarvis,
Kristen C. Hunn,
Tally M. Largent-Milnes,
Margaret E. Tome,
Thomas P. Davis

Published: February 7, 2018
https://doi.org/10.1371/journal.pone.0192340

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Opioids
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Intraperitoneal injections
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Membrane trafficking
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Central nervous system
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