Short-term repeated HRV-16 exposure results in an attenuated immune response in vivo in humans

Rebecca M. Koch; Matthijs Kox; Corné van den Kieboom; Gerben Ferwerda; Jelle Gerretsen; Sandra ten Bruggencate; Johannes G. van der Hoeven; Marien I. de Jonge; Peter Pickkers

doi:10.1371/journal.pone.0191937

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Open Access

Peer-reviewed

Research Article

Short-term repeated HRV-16 exposure results in an attenuated immune response in vivo in humans

Rebecca M. Koch,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliations Radboudumc, HB, Radboud Institute for Molecular Life Sciences, Department of Intensive Care Medicine, HB, Nijmegen, The Netherlands, Radboud center for Infectious Diseases (RCI), HB, Nijmegen, The Netherlands
⨯
Matthijs Kox ,

Roles Supervision, Visualization, Writing – review & editing

* E-mail: Matthijs.Kox@radboudumc.nl

Affiliations Radboudumc, HB, Radboud Institute for Molecular Life Sciences, Department of Intensive Care Medicine, HB, Nijmegen, The Netherlands, Radboud center for Infectious Diseases (RCI), HB, Nijmegen, The Netherlands
⨯
Corné van den Kieboom,

Roles Writing – review & editing

Affiliations Radboud center for Infectious Diseases (RCI), HB, Nijmegen, The Netherlands, Radboudumc, HB, Radboud Institute for Molecular Life Sciences, Department of Pediatrics, HB, Nijmegen, The Netherlands
⨯
Gerben Ferwerda,

Roles Supervision

Affiliations Radboud center for Infectious Diseases (RCI), HB, Nijmegen, The Netherlands, Radboudumc, HB, Radboud Institute for Molecular Life Sciences, Department of Pediatrics, HB, Nijmegen, The Netherlands
⨯
Jelle Gerretsen,

Roles Data curation, Formal analysis

Affiliations Radboudumc, HB, Radboud Institute for Molecular Life Sciences, Department of Intensive Care Medicine, HB, Nijmegen, The Netherlands, Radboud center for Infectious Diseases (RCI), HB, Nijmegen, The Netherlands
⨯
Sandra ten Bruggencate,

Roles Data curation, Software

Affiliation NIZO food research BV, ZB, Ede, The Netherlands
⨯
Johannes G. van der Hoeven,

Roles Supervision

Affiliations Radboudumc, HB, Radboud Institute for Molecular Life Sciences, Department of Intensive Care Medicine, HB, Nijmegen, The Netherlands, Radboud center for Infectious Diseases (RCI), HB, Nijmegen, The Netherlands
⨯
Marien I. de Jonge,

Roles Supervision, Visualization, Writing – review & editing

Affiliations Radboud center for Infectious Diseases (RCI), HB, Nijmegen, The Netherlands, Radboudumc, HB, Radboud Institute for Molecular Life Sciences, Department of Pediatrics, HB, Nijmegen, The Netherlands
⨯
Peter Pickkers

Roles Funding acquisition, Project administration, Resources, Supervision

Affiliations Radboudumc, HB, Radboud Institute for Molecular Life Sciences, Department of Intensive Care Medicine, HB, Nijmegen, The Netherlands, Radboud center for Infectious Diseases (RCI), HB, Nijmegen, The Netherlands
⨯

Short-term repeated HRV-16 exposure results in an attenuated immune response in vivo in humans

Rebecca M. Koch,
Matthijs Kox,
Corné van den Kieboom,
Gerben Ferwerda,
Jelle Gerretsen,
Sandra ten Bruggencate,
Johannes G. van der Hoeven,
Marien I. de Jonge,
Peter Pickkers

Published: February 15, 2018
https://doi.org/10.1371/journal.pone.0191937

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