Effects of environmental Bisphenol A exposures on germ cell development and Leydig cell function in the human fetal testis

• Soria Eladak ,

  Contributed equally to this work with: Soria Eladak, Delphine Moison

  Roles Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliations Univ. Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Genetic Stability, Stem Cells and Radiation, Fontenay-aux-Roses, France, CEA, DSV, iRCM, SCSR, LDG, Fontenay-aux-Roses, France, INSERM, Unité 967, Fontenay aux Roses, France

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• Delphine Moison ,

  Contributed equally to this work with: Soria Eladak, Delphine Moison

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliations Univ. Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Genetic Stability, Stem Cells and Radiation, Fontenay-aux-Roses, France, CEA, DSV, iRCM, SCSR, LDG, Fontenay-aux-Roses, France, INSERM, Unité 967, Fontenay aux Roses, France

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• Marie-Justine Guerquin,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision

  Affiliations Univ. Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Genetic Stability, Stem Cells and Radiation, Fontenay-aux-Roses, France, CEA, DSV, iRCM, SCSR, LDG, Fontenay-aux-Roses, France, INSERM, Unité 967, Fontenay aux Roses, France

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• Gabriele Matilionyte,

  Roles Formal analysis, Investigation, Methodology

  Affiliation MRC Centre for Reproductive Health, The University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, Scotland, United Kingdom

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• Karen Kilcoyne,

  Roles Formal analysis, Investigation, Methodology

  Affiliation MRC Centre for Reproductive Health, The University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, Scotland, United Kingdom

  ⨯
• Thierry N’Tumba-Byn,

  Roles Investigation

  Affiliations Univ. Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Genetic Stability, Stem Cells and Radiation, Fontenay-aux-Roses, France, CEA, DSV, iRCM, SCSR, LDG, Fontenay-aux-Roses, France, INSERM, Unité 967, Fontenay aux Roses, France

  ⨯
• Sébastien Messiaen,

  Roles Formal analysis, Investigation, Methodology

  Affiliations Univ. Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Genetic Stability, Stem Cells and Radiation, Fontenay-aux-Roses, France, CEA, DSV, iRCM, SCSR, LDG, Fontenay-aux-Roses, France, INSERM, Unité 967, Fontenay aux Roses, France

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• Yoann Deceuninck,

  Roles Investigation, Methodology

  Affiliation Laboratoire d’Etude des Résidus et Contaminants dans les Aliments (LABERCA), Ecole Nationale Vétérinaire Agroalimentaire et de l’Alimentation Nantes Atlantique (ONIRIS), Nantes, France

  ⨯
• Stéphanie Pozzi-Gaudin,

  Roles Investigation, Methodology

  Affiliation Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital A. Béclère, Université Paris Sud, Clamart, France

  ⨯
• Alexandra Benachi,

  Roles Investigation, Project administration

  Affiliation Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital A. Béclère, Université Paris Sud, Clamart, France

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• Gabriel Livera,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Validation

  Affiliations Univ. Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Genetic Stability, Stem Cells and Radiation, Fontenay-aux-Roses, France, CEA, DSV, iRCM, SCSR, LDG, Fontenay-aux-Roses, France, INSERM, Unité 967, Fontenay aux Roses, France

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• Jean-Philippe Antignac,

  Roles Formal analysis, Project administration, Validation

  Affiliation Laboratoire d’Etude des Résidus et Contaminants dans les Aliments (LABERCA), Ecole Nationale Vétérinaire Agroalimentaire et de l’Alimentation Nantes Atlantique (ONIRIS), Nantes, France

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• Rod Mitchell ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Validation, Writing – original draft

  ¶‡ These authors contributed equally to this work

  Affiliation MRC Centre for Reproductive Health, The University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, Scotland, United Kingdom

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• Virginie Rouiller-Fabre ,

  Roles Conceptualization, Formal analysis, Project administration, Supervision, Validation

  ¶‡ These authors contributed equally to this work

  Affiliations Univ. Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Genetic Stability, Stem Cells and Radiation, Fontenay-aux-Roses, France, CEA, DSV, iRCM, SCSR, LDG, Fontenay-aux-Roses, France, INSERM, Unité 967, Fontenay aux Roses, France

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• René Habert

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft

  * E-mail: rene.habert@cea.fr

  ¶‡ These authors contributed equally to this work

  Affiliations Univ. Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Genetic Stability, Stem Cells and Radiation, Fontenay-aux-Roses, France, CEA, DSV, iRCM, SCSR, LDG, Fontenay-aux-Roses, France, INSERM, Unité 967, Fontenay aux Roses, France

  http://orcid.org/0000-0002-6045-0324

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